Therapeutic effect of Curcuma longa L. on the nonalcoholic fatty liver disease (NAFLD) physiopathology due fructose consumption

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dc.contributor.authorHasimoto, Fabiana Kurokawa [UNESP]
dc.contributor.authorFrancisqueti-Ferron, Fabiane Valentini [UNESP]
dc.contributor.authorCosta, Mariane Róvero [UNESP]
dc.contributor.authorde Souza, Marajane Bruno [UNESP]
dc.contributor.authorAun, Aline Garcia [UNESP]
dc.contributor.authorNogueira, Flávia Ribeiro [UNESP]
dc.contributor.authorAlves, Pedro Henrique Rizzi [UNESP]
dc.contributor.authorLima, Giuseppina Pace Pereira [UNESP]
dc.contributor.authorGarcia, Jéssica Leite [UNESP]
dc.contributor.authorde Almeida Silva, Carol Cristina Vágula [UNESP]
dc.contributor.authorFerron, Artur Junio Togneri [UNESP]
dc.contributor.authorMinatel, Igor Otávio [UNESP]
dc.contributor.authorMoreto, Fernando [UNESP]
dc.contributor.authorBraz, Mariana Gobbo [UNESP]
dc.contributor.authorCorrêa, Camila Renata [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T09:00:50Z
dc.date.available2022-05-01T09:00:50Z
dc.date.issued2020-12-01
dc.description.abstractPurpose: The consumption of products containing fructose is associated with metabolic disorders and nonalcoholic fatty liver disease (NAFLD). Several pathways have been described associating the fructose intake and liver damage, among them the reduced peroxisome proliferator-activated receptor alpha (PPAR-α) expression, insulin resistance, inflammation, and oxidative stress. Curcuma longa L. is a member of the Zingiberaceae family and has traditionally been used as a medicinal herb. The aim was to verify the therapeutic effect of Curcuma longa L. in the physiopathology of NAFLD due to the fructose consumption. Methods: During 16 weeks, animals (n = 12) received standard chow + fructose in drinking water (30%) ad libitum. After, animals were randomly allocated to receive placebo treatment (fructose, n = 6) or Curcuma longa L. treatment (fructose + Cl, n = 6) for further 8 weeks. Both groups continued receiving standard chow + fructose in drinking water (30%) ad libitum. Results: Curcuma longa L. was effective to reduce insulin resistance and triglycerides levels, increase PPAR-α protein expression in liver, and attenuate macrovesicular steatosis, liver IL-6 levels, and oxidative stress (with lower protein carbonylation, MDA, and DNA damage and increase in SOD and catalase antioxidant enzymes) induced by fructose consumption. Conclusion: Curcuma longa L. treatment was effective to modulate the physiopathology of NAFLD due to fructose consumption.en
dc.description.affiliationBotucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Bairro: Distrito de Rubião Junior
dc.description.affiliationInstitute of Bioscience São Paulo State University (UNESP)
dc.description.affiliationUnespBotucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Bairro: Distrito de Rubião Junior
dc.description.affiliationUnespInstitute of Bioscience São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2016/18461-2
dc.identifierhttp://dx.doi.org/10.1186/s41110-020-00127-z
dc.identifier.citationNutrire, v. 45, n. 2, 2020.
dc.identifier.doi10.1186/s41110-020-00127-z
dc.identifier.issn2316-7874
dc.identifier.issn1519-8928
dc.identifier.scopus2-s2.0-85114376950
dc.identifier.urihttp://hdl.handle.net/11449/233504
dc.language.isoeng
dc.relation.ispartofNutrire
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectCurcumin
dc.subjectLiver
dc.subjectPolyphenols
dc.titleTherapeutic effect of Curcuma longa L. on the nonalcoholic fatty liver disease (NAFLD) physiopathology due fructose consumptionen
dc.typeArtigo
unesp.author.orcid0000-0003-2910-4308[2]

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Artigos - Química e Bioquímica - IBB