The influence of cyclosporin A on mechanical retention of dental implants previously integrated to the bone: A study in rabbits

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dc.contributor.authorSakakura, Celso E.
dc.contributor.authorMargonar, Rogerio
dc.contributor.authorSartori, Rafael
dc.contributor.authorMorais, Juliana A.N.D.
dc.contributor.authorMarcantonio Jr., Elcio
dc.contributor.institutionEducational Foundation of Barretos
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T08:43:17Z
dc.date.available2022-04-29T08:43:17Z
dc.date.issued2006-12-01
dc.description.abstractBackground: Immunosuppressive agents may induce severe changes on bone metabolism and may impair the osseointegration process during the implant healing. No data are available concerning the influence of cyclosporin A on dental implants previously integrated to the bone. The aim of this study was to evaluate the influence of cyclosporin A administration on the mechanical retention of bone previously integrated to dental implants. Methods: Eighteen female New Zealand rabbits were submitted to an implant surgery. Each animal received one commercial dental implant of 10 × 3.75 mm. After 12 weeks of an undisturbed healing period, six animals were randomly sacrificed and the removal torque test was performed (group A). In addition, six animals were submitted to a daily injection of cyclosporin A in a dosage of 10 mg/kg (group C), and six animals received saline solution as a control (group B). After 12 weeks of cyclosporin A administration, groups B and C were sacrificed and submitted to a removal torque test in which higher values can be interpreted as higher mechanical bone retention to the implant surface or higher osseointegration. Results: The removal torque results were 30.5 (±9.8) Ncm for group A, 50.17 (±17.5) Ncm for group B, and 26 (±7.8) Ncm for group C. The statistical analysis showed significant differences between groups A and B (P <0.05) and groups B and C (P<0.01). Conclusion: Cyclosporin A administration may impair the mechanical retention of dental implants previously integrated to the bone.en
dc.description.affiliationDepartment of Periodontology Educational Foundation of Barretos, Barretos, São Paulo
dc.description.affiliationDepartment of Periodontology Dental School of Araraquara State University of São Paulo, Rua Humaitá 1680, Araraquara, São Paulo
dc.format.extent2059-2062
dc.identifierhttp://dx.doi.org/10.1902/jop.2006.050290
dc.identifier.citationJournal of Periodontology, v. 77, n. 12, p. 2059-2062, 2006.
dc.identifier.doi10.1902/jop.2006.050290
dc.identifier.issn0022-3492
dc.identifier.scopus2-s2.0-33845724225
dc.identifier.urihttp://hdl.handle.net/11449/231027
dc.language.isoeng
dc.relation.ispartofJournal of Periodontology
dc.sourceScopus
dc.subjectCyclosporin A
dc.subjectDental implant
dc.subjectOsseointegration
dc.subjectTorque
dc.titleThe influence of cyclosporin A on mechanical retention of dental implants previously integrated to the bone: A study in rabbitsen
dc.typeArtigo

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