Mitochondrial Alterations in Nonalcoholic Fatty Liver Disease. Pediatric Case Description of Three Submitted Sequential Biopsies

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dc.contributor.authorDa Silva, Gustavo Henrique
dc.contributor.authorCoelho, Kunie Iabuki Rabello [UNESP]
dc.contributor.authorRabello Coelho, Claudio Antonio [UNESP]
dc.contributor.authorFazzio Escanhoela, Cecilia Amelia
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:26Z
dc.date.available2014-05-20T13:37:26Z
dc.date.issued2009-06-01
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is a clinical-pathological syndrome that encompasses a wide spectrum of morphologic alterations, ranging from simple hepatic steatosis to a more severe stage, known as nonalcoholic steatohepatitis (NASH). The purpose of this clinical report was to contribute to the understanding of mitochondrial alterations in NAFLD. The child (13-month-old) underwent initial biopsy in the year 2000 and was diagnosed with diffuse macro and microvesicular steatosis. Two additional biopsies were performed in 2001 and 2004. A high percentage of microvesicular steatosis was observed in the biopsies performed in 2000 and 2001. Mitochondrial size was slightly increased in the biopsy performed in the year 2000, significantly increased in 2001 and decreased in 2004. The presence of "mitochondrial hypertrophy" in the hepatocytes of an asymptomatic pediatric patient whose disease presentation was typical of NAFLD, excluding other pathological processes, allowed us to suspect that such a defect was considered the primary mitochondrial disorder.en
dc.description.affiliationState Univ Campinas UNICAMP, Dept Pathol, Fac Med Sci, Campinas, SP, Brazil
dc.description.affiliationState Univ São Paulo UNESP, Botucatu Sch Med, Dept Pediat, Rubiao, SP, Brazil
dc.description.affiliationState Univ São Paulo UNESP, Botucatu Sch Med, Dept Pathol, Rubiao, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo UNESP, Botucatu Sch Med, Dept Pediat, Rubiao, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo UNESP, Botucatu Sch Med, Dept Pathol, Rubiao, SP, Brazil
dc.format.extent215-219
dc.identifierhttp://www.jgld.ro/2009/2/13.html
dc.identifier.citationJournal of Gastrointestinal and Liver Diseases. Cluj-napoca: Medical Univ Press, v. 18, n. 2, p. 215-219, 2009.
dc.identifier.issn1841-8724
dc.identifier.urihttp://hdl.handle.net/11449/12954
dc.identifier.wosWOS:000280320400018
dc.language.isoeng
dc.publisherMedical Univ Press
dc.relation.ispartofJournal of Gastrointestinal and Liver Diseases
dc.relation.ispartofjcr1.964
dc.relation.ispartofsjr0,647
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNAFLDen
dc.subjectmicrovesicular steatosisen
dc.subjectmitochondrial alterationsen
dc.subjectliveren
dc.titleMitochondrial Alterations in Nonalcoholic Fatty Liver Disease. Pediatric Case Description of Three Submitted Sequential Biopsiesen
dc.typeArtigo
dcterms.rightsHolderMedical Univ Press
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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