Avaliação histomorfométrica em testículo e epidídimo de ratos com enfisema pulmonar induzido experimentalmente por exposição prolongada à fumaça de cigarro

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dc.contributor.authorRibeiro, Amanda de Gênova [UNESP]
dc.contributor.authorRibeiro-Paes, João Tadeu [UNESP]
dc.contributor.authorStessuk, Talita
dc.contributor.authorKozma, Rodrigo de las Heras
dc.contributor.authorCamargo, Isabel Cristina Cherici [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:29:06Z
dc.date.available2018-12-11T17:29:06Z
dc.date.issued2016-07-01
dc.description.abstractThe study evaluated the histomorphometrical aspects of testis and epididymis of adult rats with pulmonary emphysema experimentally induced by exposure to cigarette smoke for 30 weeks. Previous studies related to effects of the cigarette smoke on male reproductive tissue were performed in relatively shorter time periods and thus, it does not allow a direct correlation between smoke exposure and damage to reproductive structures like testis and epididymis. In order to evaluate the effect of cigarette smoke for long period on the testis and epididymis, twelve adult Wistar rats were divided into two groups: Control (CG; exposed to ambient air) and Smoking (SG; exposed to cigarette smoke). The weight of the testes, epididymides, seminal glands and prostate were not affected (p>0.05) by experimental treatment. In the SG, the testes presented cellular desquamation, significant decrease in the number of germ cells and Sertoli cell, and reduction (p<0.05) in area and diameter of seminiferous tubules. The exposure of animals to cigarette smoke did not promoted histological changes in the epididymis, but decreased significantly the ductular area and epithelial height in the caput and corpus regions. It was concluded that testis was more susceptible than the epididymis to the effects of cigarette smoke constituents in rats with pulmonary emphysema experimentally induced by prolonged cigarette-smoke exposure.en
dc.description.affiliationUniversidade Estadual Paulista UNESP
dc.description.affiliationDepartamento de Ciências Biológicas UNESP
dc.description.affiliationUniversidade de São Paulo – USP
dc.description.affiliationDepartamento de Ciências Biológicas Universidade Estadual Paulista UNESP
dc.description.affiliationUnespUniversidade Estadual Paulista UNESP
dc.description.affiliationUnespDepartamento de Ciências Biológicas UNESP
dc.description.affiliationUnespDepartamento de Ciências Biológicas Universidade Estadual Paulista UNESP
dc.format.extent1092-1102
dc.identifierhttp://dx.doi.org/10.14393/BJ-v32n4a2016-33925
dc.identifier.citationBioscience Journal, v. 32, n. 4, p. 1092-1102, 2016.
dc.identifier.doi10.14393/BJ-v32n4a2016-33925
dc.identifier.issn1981-3163
dc.identifier.issn1516-3725
dc.identifier.scopus2-s2.0-84979018676
dc.identifier.urihttp://hdl.handle.net/11449/178164
dc.language.isoeng
dc.relation.ispartofBioscience Journal
dc.relation.ispartofsjr0,303
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectComorbities
dc.subjectPulmonary emphysema
dc.subjectReproductive toxicology
dc.subjectTobacco
dc.titleAvaliação histomorfométrica em testículo e epidídimo de ratos com enfisema pulmonar induzido experimentalmente por exposição prolongada à fumaça de cigarropt
dc.title.alternativeHistomorphometrical evaluation in testis and epididymis of rats with pulmonary emphysema experimentally induced by prolonged exposure to cigarette smokeen
dc.typeArtigo
unesp.departmentCiências Biológicas - FCLASpt

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