Ultrasound-assisted synthesis of organotin compounds and their application as luminescent dye in silk fibroin scaffolds

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dc.contributor.authorLara-Cerón, Jesús A.
dc.contributor.authorJiménez-Pérez, Víctor M.
dc.contributor.authorMolina-Paredes, Areli A.
dc.contributor.authorOchoa, María E.
dc.contributor.authorSábio, Rafael M.
dc.contributor.authorAmaral, André C.
dc.contributor.authorda Silva, Robson R.
dc.contributor.authorRibeiro, Sidney J.L. [UNESP]
dc.contributor.authorda S. Barud, Hernane
dc.contributor.authorMuñoz-Flores, Blanca M.
dc.contributor.institutionFacultad de Ciencias Químicas
dc.contributor.institutionCentro de Investigación y de Estudios Avanzados del IPN
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionLaboratory of Polymers and Biomaterials University of Araraquara (UNIARA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:34:53Z
dc.date.available2020-12-12T02:34:53Z
dc.date.issued2020-05-24
dc.description.abstractIn this work, we report the green synthesis of four luminescent organotin compounds 1–4 derived from amino acid Schiff bases (1: Naph-Trp-SnPh2, 2: Naph-Tyr-SnBu2, 3: Naph-Tyr-SnPh2, 4: Naph-Phe-SnPh2), obtained by ultrasound-assisted synthesis in short time (~20 min) and good yields (>95%). The molecular structure proposed in solution (1H and 119Sn NMR) was confirmed by X-ray diffraction study for compound 1 where the tin atom resides in trigonal bipyramid geometry. Luminescent silk fibroin scaffolds (SF 1–4) were elaborated with organotin compounds by freeze-drying technique. Photophysical properties of organotin compounds and scaffolds were obtained in solid state, observing bathochromic behaviors in tyrosine derived compounds, suggesting that the tyrosine produce supramolecular interactions across the –OH group that change the fluorescent properties. Scaffolds 1–4 were characterized by FTIR, XDR, TG/DTG, and SEM analysis. In addition, cytotoxic analysis of SF 1 presents high cellular viability, which could be applied as a scaffold in tissue engineering.en
dc.description.affiliationUniversidad Autónoma de Nuevo León Facultad de Ciencias Químicas, Ciudad Universitaria, Av. Universidad s/n
dc.description.affiliationDepartamento de Química Centro de Investigación y de Estudios Avanzados del IPN, A. P. 14-740
dc.description.affiliationSão Carlos Institute of Physics – University of São Paulo (USP)
dc.description.affiliationLaboratory of Polymers and Biomaterials University of Araraquara (UNIARA)
dc.description.affiliationDepartment of Chemistry and Chemical Engineering Chalmers University of Technology
dc.description.affiliationInstitute of Chemistry São Paulo State University - Unesp, CP355, Zip Code 14801-970
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University - Unesp, CP355, Zip Code 14801-970
dc.identifierhttp://dx.doi.org/10.1016/j.ica.2020.119490
dc.identifier.citationInorganica Chimica Acta, v. 505.
dc.identifier.doi10.1016/j.ica.2020.119490
dc.identifier.issn0020-1693
dc.identifier.scopus2-s2.0-85079048268
dc.identifier.urihttp://hdl.handle.net/11449/201528
dc.language.isoeng
dc.relation.ispartofInorganica Chimica Acta
dc.sourceScopus
dc.subjectFluorescence
dc.subjectOrganotin
dc.subjectScaffold silk fibroin
dc.subjectUltrasound-assisted synthesis
dc.subjectX-ray
dc.titleUltrasound-assisted synthesis of organotin compounds and their application as luminescent dye in silk fibroin scaffoldsen
dc.typeArtigo

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