The Role of Dyslipidemia in Periodontitis

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dc.contributor.authorBitencourt, Fernando Valentim
dc.contributor.authorNascimento, Gustavo G.
dc.contributor.authorCosta, Susilena Arouche
dc.contributor.authorOrrico, Silvana Regina Perez [UNESP]
dc.contributor.authorRibeiro, Cecilia Claudia Costa
dc.contributor.authorLeite, Fábio Renato Manzolli
dc.contributor.institutionAarhus University
dc.contributor.institutionSteno Diabetes Center Aarhus
dc.contributor.institutionNational Dental Research Institute Singapore
dc.contributor.institutionDuke-NUS Medical School
dc.contributor.institutionFederal University of Maranhão
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUnion of the Colleges of the Great Lakes (UNILAGO)
dc.date.accessioned2023-07-29T13:38:44Z
dc.date.available2023-07-29T13:38:44Z
dc.date.issued2023-01-01
dc.description.abstractStudies have suggested an important role of dyslipidemia, a condition with alterations in blood lipid levels, in promoting an additional effect on periodontal breakdown. Thus, this study aimed to explore the theoretical pathways associated with dyslipidemia and periodontitis. We used data from 11,917 US adults with complete periodontal examinations participating in the Third National Health and Nutrition Examination Survey (NHANES III). Our hypothesis was tested using structural equation modelling (SEM). Dyslipidemia was defined according to the National Cholesterol Education Program (NCEP-ATP III) and periodontitis as a latent variable reflecting the shared variance of the number of surfaces with periodontal pocket depth [PPD] = 4 mm, PPD = 5 mm, PPD ≥ 6 mm, clinical attachment level [CAL] = 4 mm, CAL = 5mm, CAL ≥ 6 mm, and furcation involvement. The model also considered distal determinants (age, sex, and socioeconomic status) and proximal determinants (HbA1c, smoking and alcohol consumption, and obesity). The model showed sufficient global fit (Root Mean Squared Error of Approximation = 0.04, 90%CI = 0.04–0.05, Tucker–Lewis Index = 0.93, Comparative Fit Index = 0.95). Age, sex, socioeconomic status, obesity, and smoking were directly associated with periodontitis (p < 0.01). Dyslipidemia revealed a significant direct effect on periodontitis (standardized coefficient [SC] = 0.086, SE 0.027; p < 0.01), also mediated via an indirect pathway through HbA1c (SC = 0.021; SE 0.010; p = 0.02) and obesity (SC = 0.036; SE 0.012; p < 0.01) and resulted in a total effect on periodontitis. Dyslipidemia was associated with periodontitis through a direct pathway and indirectly through HbA1c and obesity in the US population. These results support the need for a multi-professional approach to tackling oral and noncommunicable diseases (NCDs), directed at their common risk factors.en
dc.description.affiliationDepartment of Dentistry and Oral Health Section for Periodontology Aarhus University
dc.description.affiliationSteno Diabetes Center Aarhus
dc.description.affiliationNational Dental Centre Singapore National Dental Research Institute Singapore
dc.description.affiliationOral Health Academic Clinical Programme Duke-NUS Medical School
dc.description.affiliationGraduate Dentistry Program Federal University of Maranhão
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University (UNESP)
dc.description.affiliationAdvanced Research Center in Medicine Union of the Colleges of the Great Lakes (UNILAGO)
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/nu15020300
dc.identifier.citationNutrients, v. 15, n. 2, 2023.
dc.identifier.doi10.3390/nu15020300
dc.identifier.issn2072-6643
dc.identifier.scopus2-s2.0-85146759576
dc.identifier.urihttp://hdl.handle.net/11449/248253
dc.language.isoeng
dc.relation.ispartofNutrients
dc.sourceScopus
dc.subjectdiabetes mellitus
dc.subjectdyslipidemias
dc.subjectnon-communicable diseases
dc.subjectperiodontal diseases
dc.subjectpublic health dentistry
dc.subjectsystemic disease
dc.titleThe Role of Dyslipidemia in Periodontitisen
dc.typeArtigo
unesp.author.orcid0000-0002-7310-2767[1]
unesp.author.orcid0000-0002-4288-6300[2]
unesp.author.orcid0000-0002-9010-7930[3]
unesp.author.orcid0000-0002-8053-4517[6]

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