Experimental alcoholism and pathogenesis of prostatic diseases in UChB rats

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dc.contributor.authorCandido, Eduardo Marcelo
dc.contributor.authorFabrega Carvalho, Cesar Alexandre
dc.contributor.authorMartinez, Francisco Eduardo
dc.contributor.authorAlves Cagnon, Valeria Helena
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:53Z
dc.date.available2014-05-20T15:22:53Z
dc.date.issued2007-05-01
dc.description.abstractPrevious studies have shown that long-term alcohol treatment has negative effects on prostatic stromal-epithelial interaction. Thus, the aim of the present study was to analyze the histochemical, immunohistochemical and ultrastructural alterations that occur in the prostatic stroma and epithelium of rats submitted to chronic alcohol ingestion and alcohol abstinence, as well as to establish the relationship between these changes and prostatic diseases. Thirty male rats (10 Wistar and 20 UChB rats) were divided into three experimental groups: the control group received tap water, the alcoholic group received ethanol diluted to 10 degrees G.L. for 150 days, and the abstinent group received the same liquid diet as the alcoholic group up to 120 days of treatment and only tap water for 30 days thereafter. At the end of treatment, all animals were sacrificed and the ventral lobe of the prostate was removed and processed for histochemical, immunohistochemical and ultrastructural analyses. In addition, plasma testosterone levels were measured. The results showed, prostatic intraepithelial neoplasia, infolding of the epithelium towards the stroma, stromal hypertrophy and the presence of inflammatory cells in alcoholic animals. In the abstinent group, alterations were noted mainly in the stromal area. In conclusion, ethanol triggers alterations in prostatic epithelial and stromal compartments, affecting the stromal microenvironment and predisposing the organ to pathological processes. (C) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Dept Anat, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationState Univ São Paulo, Inst Biosci, Dept Anat, São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Inst Biosci, Dept Anat, São Paulo, Brazil
dc.format.extent459-472
dc.identifierhttp://dx.doi.org/10.1016/j.cellbi.2006.11.009
dc.identifier.citationCell Biology International. London: Academic Press Ltd Elsevier B.V. Ltd, v. 31, n. 5, p. 459-472, 2007.
dc.identifier.doi10.1016/j.cellbi.2006.11.009
dc.identifier.issn1065-6995
dc.identifier.lattes1739564105219382
dc.identifier.urihttp://hdl.handle.net/11449/33792
dc.identifier.wosWOS:000246450000005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCell Biology International
dc.relation.ispartofjcr1.936
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalcoholismpt
dc.subjectUChB ratpt
dc.subjectprostatept
dc.subjectstromal-epithelial interactionpt
dc.subjectmorphologypt
dc.titleExperimental alcoholism and pathogenesis of prostatic diseases in UChB ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1739564105219382
unesp.author.orcid0000-0002-9317-344X[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Anatomia - IBB