Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats

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dc.contributor.authorLevi, Yara L. A. S.
dc.contributor.authorNovais, Gabriela S.
dc.contributor.authorDias, Raisa B.
dc.contributor.authorAndraus, Rodrigo A. C.
dc.contributor.authorMessora, Michel R.
dc.contributor.authorNeto, Hermann B.
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorSantinoni, Carolina S.
dc.contributor.authorMaia, Luciana P.
dc.contributor.institutionUniversity of Western Sao Paulo—UNOESTE
dc.contributor.institutionUniversity Pitagoras UNOPAR Parana
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity Pitagoras UNOPAR
dc.date.accessioned2018-12-11T17:22:32Z
dc.date.available2018-12-11T17:22:32Z
dc.date.issued2018-09-01
dc.description.abstractAim: To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. Materials and Methods: Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP-PREB. Groups PREB and EP-PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP-PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p < 0.05). Results: Group EP-PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP (p < 0.05). It was also observed a significant decrease in IL-10 and IFN-γ gene expression, besides a decrease in TNF-α and IL-1β and an increase in TGF-β immunolabeling score for group EP-PREB. Group EP-PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values (p < 0.05). Conclusion: It can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune-inflammatory parameters, in addition to protecting the intestine.en
dc.description.affiliationGraduate Program in Dentistry (GPD—Master's Degree) University of Western Sao Paulo—UNOESTE
dc.description.affiliationGraduate Program in Rehabilitation Sciences University Pitagoras UNOPAR Parana
dc.description.affiliationDepartament of Oral and Maxillofacial Surgery and Periodontology School of Dentistry of Ribeirão Preto University of Sao Paulo—USP
dc.description.affiliationDepartment of Functional Sciences University of Western Sao Paulo—UNOESTE
dc.description.affiliationDivision of Histology Department of Basic Sciences Dental School of Aracatuba University Estadual Paulista—UNESP
dc.description.affiliationGraduate Program in Dentistry University Pitagoras UNOPAR
dc.description.affiliationUnespDivision of Histology Department of Basic Sciences Dental School of Aracatuba University Estadual Paulista—UNESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/02564-4
dc.format.extent1078-1089
dc.identifierhttp://dx.doi.org/10.1111/jcpe.12987
dc.identifier.citationJournal of Clinical Periodontology, v. 45, n. 9, p. 1078-1089, 2018.
dc.identifier.doi10.1111/jcpe.12987
dc.identifier.issn1600-051X
dc.identifier.issn0303-6979
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85052846183
dc.identifier.urihttp://hdl.handle.net/11449/176795
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Periodontology
dc.relation.ispartofsjr2,079
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectalveolar bone loss
dc.subjectanimal model
dc.subjectinflammation
dc.subjectperiodontal diseases
dc.subjectperiodontitis
dc.subjectprebiotics
dc.titleEffects of the prebiotic mannan oligosaccharide on the experimental periodontitis in ratsen
dc.typeArtigo
unesp.author.lattes4408095517346846[7]
unesp.author.orcid0000-0001-8485-9645[5]
unesp.author.orcid0000-0001-5697-2587[9]
unesp.author.orcid0000-0003-4859-0583[7]

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