Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats
dc.contributor.author | Levi, Yara L. A. S. | |
dc.contributor.author | Novais, Gabriela S. | |
dc.contributor.author | Dias, Raisa B. | |
dc.contributor.author | Andraus, Rodrigo A. C. | |
dc.contributor.author | Messora, Michel R. | |
dc.contributor.author | Neto, Hermann B. | |
dc.contributor.author | Ervolino, Edilson [UNESP] | |
dc.contributor.author | Santinoni, Carolina S. | |
dc.contributor.author | Maia, Luciana P. | |
dc.contributor.institution | University of Western Sao Paulo—UNOESTE | |
dc.contributor.institution | University Pitagoras UNOPAR Parana | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | University Pitagoras UNOPAR | |
dc.date.accessioned | 2018-12-11T17:22:32Z | |
dc.date.available | 2018-12-11T17:22:32Z | |
dc.date.issued | 2018-09-01 | |
dc.description.abstract | Aim: To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. Materials and Methods: Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP-PREB. Groups PREB and EP-PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP-PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p < 0.05). Results: Group EP-PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP (p < 0.05). It was also observed a significant decrease in IL-10 and IFN-γ gene expression, besides a decrease in TNF-α and IL-1β and an increase in TGF-β immunolabeling score for group EP-PREB. Group EP-PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values (p < 0.05). Conclusion: It can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune-inflammatory parameters, in addition to protecting the intestine. | en |
dc.description.affiliation | Graduate Program in Dentistry (GPD—Master's Degree) University of Western Sao Paulo—UNOESTE | |
dc.description.affiliation | Graduate Program in Rehabilitation Sciences University Pitagoras UNOPAR Parana | |
dc.description.affiliation | Departament of Oral and Maxillofacial Surgery and Periodontology School of Dentistry of Ribeirão Preto University of Sao Paulo—USP | |
dc.description.affiliation | Department of Functional Sciences University of Western Sao Paulo—UNOESTE | |
dc.description.affiliation | Division of Histology Department of Basic Sciences Dental School of Aracatuba University Estadual Paulista—UNESP | |
dc.description.affiliation | Graduate Program in Dentistry University Pitagoras UNOPAR | |
dc.description.affiliationUnesp | Division of Histology Department of Basic Sciences Dental School of Aracatuba University Estadual Paulista—UNESP | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: 2015/02564-4 | |
dc.format.extent | 1078-1089 | |
dc.identifier | http://dx.doi.org/10.1111/jcpe.12987 | |
dc.identifier.citation | Journal of Clinical Periodontology, v. 45, n. 9, p. 1078-1089, 2018. | |
dc.identifier.doi | 10.1111/jcpe.12987 | |
dc.identifier.issn | 1600-051X | |
dc.identifier.issn | 0303-6979 | |
dc.identifier.lattes | 4408095517346846 | |
dc.identifier.orcid | 0000-0003-4859-0583 | |
dc.identifier.scopus | 2-s2.0-85052846183 | |
dc.identifier.uri | http://hdl.handle.net/11449/176795 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Clinical Periodontology | |
dc.relation.ispartofsjr | 2,079 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Scopus | |
dc.subject | alveolar bone loss | |
dc.subject | animal model | |
dc.subject | inflammation | |
dc.subject | periodontal diseases | |
dc.subject | periodontitis | |
dc.subject | prebiotics | |
dc.title | Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats | en |
dc.type | Artigo | |
unesp.author.lattes | 4408095517346846[7] | |
unesp.author.orcid | 0000-0001-8485-9645[5] | |
unesp.author.orcid | 0000-0001-5697-2587[9] | |
unesp.author.orcid | 0000-0003-4859-0583[7] |