Roeky Mountain Spotted Fever Vaccine: A Regional Need
| dc.contributor.author | Walker, David H. | |
| dc.contributor.author | Montenegro, Mario R. [UNESP] | |
| dc.contributor.author | Hegarty, Barbara C. | |
| dc.contributor.author | Tringali, Giuseppe R. | |
| dc.contributor.institution | School of Medicine | |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
| dc.contributor.institution | Universita di Palermo | |
| dc.date.accessioned | 2022-04-28T19:53:45Z | |
| dc.date.available | 2022-04-28T19:53:45Z | |
| dc.date.issued | 1984-01-01 | |
| dc.description.abstract | Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in some medical practices in the southeastern United States because of the life-threatening nature of the disease, including the possibility of a fulminant course and the frequent difficulty in diagnosis. Further studies should be pursued toward the goal of developing an effective vaccine against Rocky Mountain spotted fever. © 1984 Southern Medical Association. | en |
| dc.description.affiliation | Department of Pathology University of North Carolina School of Medicine, Chapel Hill | |
| dc.description.affiliation | Department of Pathology Universidade Estadual Paulista, Botucatu, SP | |
| dc.description.affiliation | Instituto d’lgiene Universita di Palermo | |
| dc.description.affiliationUnesp | Department of Pathology Universidade Estadual Paulista, Botucatu, SP | |
| dc.format.extent | 447-449 | |
| dc.identifier | http://dx.doi.org/10.1097/00007611-198404000-00009 | |
| dc.identifier.citation | Southern Medical Journal, v. 77, n. 4, p. 447-449, 1984. | |
| dc.identifier.doi | 10.1097/00007611-198404000-00009 | |
| dc.identifier.issn | 1541-8243 | |
| dc.identifier.issn | 0038-4348 | |
| dc.identifier.scopus | 2-s2.0-0021333218 | |
| dc.identifier.uri | http://hdl.handle.net/11449/223905 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Southern Medical Journal | |
| dc.source | Scopus | |
| dc.title | Roeky Mountain Spotted Fever Vaccine: A Regional Need | en |
| dc.type | Artigo |