Influence of cyclosporin A on quality of bone around integrated dental implants: a radiographic study in rabbits

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dc.contributor.authorSakakura, Celso Eduardo
dc.contributor.authorMarcantonio, Elcio
dc.contributor.authorWenzel, Ann
dc.contributor.authorScaf, Gulnara [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Aarhus
dc.date.accessioned2014-02-26T17:28:00Z
dc.date.accessioned2014-05-20T13:45:10Z
dc.date.available2014-02-26T17:28:00Z
dc.date.available2014-05-20T13:45:10Z
dc.date.issued2007-02-01
dc.description.abstractTo evaluate the influence of cyclosporin A (CsA) administration on bone around integrated dental implants assessed by a bone quality index and by quantitative subtraction radiography.A total of 36 machine surface commercial implants were placed in 18 adult rabbits. After a 3-month healing period without any disturbance, the animals were randomly divided into three groups of six animals each. Group A was sacrificed at this time. CsA was injected subcutaneously in an immunosuppressive dose of 10 mg/kg/day in a test group (Group T), and a Group B served as a control, receiving only vehicle. After 3 months of cyclosporin administration, the animals of both Groups B and T were sacrificed. Radiographs were obtained at implant surgery and at the day of sacrifice with a CMOS sensor. Bone quality around the implants was compared between the groups using a bone quality index and quantitative subtraction radiography.The bone analysis showed that in Group T, the bone quality changed dramatically from a dense cortical to a loose trabecular bone structure (P < 0.0001, chi(2) test) while in Groups A and B there were no significant differences. Quantitative digital subtraction radiography showed significantly (P < 0.05) lower gray shade values (radiographic density) in a region of bone formation around the implants in Group T (118 +/- 12) than in Groups A (161 +/- 6) and B (186 +/- 10).Within the limits of this study, CsA administration has a negative effect on the quality of bone around integrated dental implant.en
dc.description.affiliationUNESP, Fac Odontol Araraquara, Dept Diagnost & Cirugia, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Aarhus, Fac Hlth Sci, Sch Dent, Dept Oral Radiol, Aarhus, Denmark
dc.description.affiliationUnespUNESP, Fac Odontol Araraquara, Dept Diagnost & Cirugia, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.format.extent34-39
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0501.2006.01253.x
dc.identifier.citationClinical Oral Implants Research. Oxford: Blackwell Publishing, v. 18, n. 1, p. 34-39, 2007.
dc.identifier.doi10.1111/j.1600-0501.2006.01253.x
dc.identifier.issn0905-7161
dc.identifier.urihttp://hdl.handle.net/11449/15877
dc.identifier.wosWOS:000243442100006
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofClinical Oral Implants Research
dc.relation.ispartofjcr4.305
dc.relation.ispartofsjr2,462
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbone densitypt
dc.subjectcyclosporinpt
dc.subjectsubtraction radiographpt
dc.subjecttitanium implantspt
dc.titleInfluence of cyclosporin A on quality of bone around integrated dental implants: a radiographic study in rabbitsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
unesp.author.orcid0000-0002-9660-4524[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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