Chitosan enhances the antimicrobial photodynamic inactivation mediated by Photoditazine® against Streptococcus mutans

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dc.contributor.authorde Souza, Cheyenne Marçal [UNESP]
dc.contributor.authorGarcia, Maíra Terra [UNESP]
dc.contributor.authorde Barros, Patrícia Pimentel [UNESP]
dc.contributor.authorPedroso, Lara Luise Castro [UNESP]
dc.contributor.authorWard, Rafael Araújo da Costa [UNESP]
dc.contributor.authorStrixino, Juliana Ferreira
dc.contributor.authorMelo, Vânia Maria Maciel
dc.contributor.authorJunqueira, Juliana Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Vale do Paraíba/UNIVAP
dc.contributor.institutionCeará Federal University
dc.date.accessioned2021-06-25T11:05:00Z
dc.date.available2021-06-25T11:05:00Z
dc.date.issued2020-12-01
dc.description.abstractChitosan (CS), a biopolymer with intrinsic antimicrobial activity, can increase antimicrobial photodynamic inactivation (aPDI). The aim of this study was to evaluate the capacity of CS to potentiate the efficacy of Photoditazine® (PDZ)-mediated aPDI of the cariogenic bacterium Streptococcus mutans. CS effectively augmented the effects of aPDI, with reductions of approximately 4.5 logs in both planktonic and biofilm states. The combined treatment was also capable of reducing the number of S. mutans cells and amount of extracellular matrix in biofilms formed on enamel surfaces, which were characterized using scanning electron microscopy analysis. Furthermore, CS increased the absorption of PDZ by S. mutans cells. The combination of CS with PDZ-mediated aPDI is hence a promising antimicrobial approach against S. mutans and may be useful to control dental caries.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University/UNESP
dc.description.affiliationFotobiologia Aplicada à Saúde (FOTOBIOS) Instituto de Pesquisa e Desenvolvimento (IP&D) Universidade do Vale do Paraíba/UNIVAP
dc.description.affiliationDepartment of Biology Laboratory of Microbial Ecology and Biotechnology Pici Ceará Federal University
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University/UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2020.102001
dc.identifier.citationPhotodiagnosis and Photodynamic Therapy, v. 32.
dc.identifier.doi10.1016/j.pdpdt.2020.102001
dc.identifier.issn1873-1597
dc.identifier.issn1572-1000
dc.identifier.scopus2-s2.0-85092065166
dc.identifier.urihttp://hdl.handle.net/11449/208020
dc.language.isoeng
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.sourceScopus
dc.subjectAntimicrobial photodynamic inactivation
dc.subjectChitosan
dc.subjectPhotoditazine®
dc.subjectStreptococcus mutans
dc.titleChitosan enhances the antimicrobial photodynamic inactivation mediated by Photoditazine® against Streptococcus mutansen
dc.typeArtigo
unesp.author.orcid0000-0003-0693-0367[1]
unesp.author.orcid0000-0002-1193-2909[2]
unesp.author.orcid0000-0003-4885-2811[3]
unesp.author.orcid0000-0002-9902-9561[4]
unesp.author.orcid0000-0003-4748-1756[5]
unesp.author.orcid0000-0001-7128-6817[6]
unesp.author.orcid0000-0002-3302-8857[7]
unesp.author.orcid0000-0001-6646-6856[8]

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