Interleukin 10 and tumor necrosis factor-alpha in pregnancy: aspects of interest in clinical obstetrics

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dc.contributor.authorMoreli, Jusciele Brogin [UNESP]
dc.contributor.authorRuocco, Ana Maria Cirino
dc.contributor.authorVernini, Joice Monaliza
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorCalderon, Iracema Mattos Paranhos
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:30:10Z
dc.date.available2015-12-07T15:30:10Z
dc.date.issued2012
dc.description.abstractThe purpose of this study was to review the literature regarding the action of the cytokines interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnancy and to emphasize the factors that are of interest to clinical obstetrics. The literature highlights several actions of IL-10 and TNF-α during pregnancy. The actions of these cytokines seem to be antagonistic and dependent on the balance between them, which is orchestrated by the specific immunosuppressive action of IL-10. TNF-α has a characteristic inflammatory action, and it is an additional diabetogenic factor in pregnancy. The loss of the control of the production of these cytokines, with increase of TNF-α, is related to the risk for developing obstetric complications, particularly recurrent fetal loss, gestational diabetes mellitus, hypertensive syndromes, and fetal growth restriction. However, study results are controversial and are not clearly defined. These issues are attributed to the heterogeneity of the studies, particularly regarding their sample sizes and sources, the evaluation methods, and the multiplicity of factors and conditions that influence cytokine production. These questions are fundamental and should be addressed in future investigations to obtain more consistent results that can be applied to obstetric practice.en
dc.description.affiliationPost-Graduate Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, (UNESP) São Paulo State University, 18618-000 Botucatu, SP, Brazil.
dc.description.affiliationUnespPost-Graduate Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, (UNESP) São Paulo State University, 18618-000 Botucatu, SP, Brazil.
dc.identifierhttp://dx.doi.org/10.5402/2012/230742
dc.identifier.citationIsrn Obstetrics And Gynecology, v. 2012, 2012.
dc.identifier.doi10.5402/2012/230742
dc.identifier.filePMC3302063.pdf
dc.identifier.issn2090-4444
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.pmcPMC3302063
dc.identifier.pubmed22462002
dc.identifier.urihttp://hdl.handle.net/11449/130919
dc.language.isoeng
dc.publisherIsrn Obstetrics And Gynecology
dc.relation.ispartofIsrn Obstetrics And Gynecology
dc.relation.ispartofsjr0,237
dc.rights.accessRightsAcesso aberto
dc.sourcePubMed
dc.titleInterleukin 10 and tumor necrosis factor-alpha in pregnancy: aspects of interest in clinical obstetricsen
dc.typeArtigo
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0002-9227-832X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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