Leprosy: a review of laboratory and therapeutic aspects - Part 2

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dc.contributor.authorLastoria, Joel Carlos [UNESP]
dc.contributor.authorAbreu, Marilda Aparecida Milanez Morgado De
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.date.accessioned2014-09-30T18:18:29Z
dc.date.available2014-09-30T18:18:29Z
dc.date.issued2014-06-01
dc.description.abstractLeprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or classify its clinical form. This article aims to update dermatologists on leprosy, through a review of complementary laboratory techniques that can be employed for the diagnosis of leprosy, including Mitsuda intradermal reaction, skin smear microscopy, histopathology, serology, immunohistochemistry, polymerase chain reaction, imaging tests, electromyography, and blood tests. It also aims to explain standard multidrug therapy regimens, the treatment of reactions and resistant cases, immunotherapy with bacillus Calmette-Guérin (BCG) vaccine and chemoprophylaxis.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu
dc.description.affiliationUniversidade do Oeste Paulista Hospital Regional de Presidente Prudente
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu
dc.format.extent389-401
dc.identifierhttp://dx.doi.org/10.1590/abd1806-4841.20142460
dc.identifier.citationAnais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 3, p. 389-401, 2014.
dc.identifier.doi10.1590/abd1806-4841.20142460
dc.identifier.fileS0365-05962014000300389.pdf
dc.identifier.issn0365-0596
dc.identifier.lattes9531498781164017
dc.identifier.scieloS0365-05962014000300389
dc.identifier.urihttp://hdl.handle.net/11449/109581
dc.identifier.wosWOS:000337911100001
dc.language.isoeng
dc.publisherSociedade Brasileira de Dermatologia
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.relation.ispartofjcr0.884
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectClinical evolutionen
dc.subjectCommunicable disease preventionen
dc.subjectDiagnosis, differentialen
dc.subjectDrug resistanceen
dc.subjectEducation, continuingen
dc.subjectLaboratory researchen
dc.subjectLeprosyen
dc.subjectMycobacterium lepraeen
dc.subjectPrognosisen
dc.subjectTherapeuticsen
dc.titleLeprosy: a review of laboratory and therapeutic aspects - Part 2en
dc.typeArtigo
unesp.author.lattes9531498781164017
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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