Comportamento de variáveis cardíacas em animais expostos à fumaça de cigarro

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dc.contributor.authorDe Paiva, Sergio Alberto Rupp [UNESP]
dc.contributor.authorMamede Zornoff, Leonardo Antonío [UNESP]
dc.contributor.authorPolití Okoshi, Marina [UNESP]
dc.contributor.authorOkoshi, Katashí [UNESP]
dc.contributor.authorCarlos-Cicogna, Antonio [UNESP]
dc.contributor.authorOscar Campana, Alvaro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:47:13Z
dc.date.available2022-04-29T08:47:13Z
dc.date.issued2003-09-01
dc.description.abstractObjective - To assess the behavior of cardiac variables in animals exposed to cigarette smoke. Methods - Two groups of Wistar rats were studied as follows: control group (C), comprising 28 animals; and smoking group (S), comprising 23 animals exposed to cigarette smoke for 30 days. Left ventricular cardiac function was assessed in vivo with transthoracic echocardiography, and myocardial performance was analyzed in vitro in preparations of isolated left ventricular papillary muscle. The cardiac muscle was assessed in isometric contractions with an extracellular calcium concentration of 2.5 mmol/L. Results - No statistical difference was observed in the values of the body variables of the rats and in the mechanical data obtained from the papillary muscle between the control and smoking groups. The values of left ventricular systolic diameter were significantly greater in the smoking animals than in the control animals (C=3.39 ± 0.4 mm and S=3.71 ± 0.51 mm, P=0.02). A significant reduction was observed in systolic shortening fraction (C=56.7 ± 4.2% and S=53.5 ± 5.3%, P=0.02) and in ejection fraction (C= 0.92 ± 0.02 and S=0.89 ± 0.04, P=0.01). Conclusion - The rats exposed to cigarette smoke had a reduction in left ventricular systolicfunction, although their myocardial function was preserved.en
dc.description.affiliationFaculdade de Medicina de Botucatu UNESP, 18618-000-Botucatu, SP
dc.description.affiliationUnespFaculdade de Medicina de Botucatu UNESP, 18618-000-Botucatu, SP
dc.format.extent221-228
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 81, n. 3, p. 221-228, 2003.
dc.identifier.issn0066-782X
dc.identifier.scopus2-s2.0-0141961116
dc.identifier.urihttp://hdl.handle.net/11449/231721
dc.language.isopor
dc.language.isoeng
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.sourceScopus
dc.subjectCigarette
dc.subjectEchocardiography
dc.subjectLeft ventricular junction
dc.subjectSmoking
dc.titleComportamento de variáveis cardíacas em animais expostos à fumaça de cigarropt
dc.title.alternativeBehavior of cardiac variables in animals exposed to cigarette smokeen
dc.typeArtigo

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