The role of cytokines in inflammatory bone loss

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dc.contributor.authorSouza, Pedro P. C. [UNESP]
dc.contributor.authorLerner, Ulf H.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUmeå University
dc.contributor.institutionSahlgrenska Academy at University of Gothenburg
dc.date.accessioned2014-05-27T11:30:41Z
dc.date.available2014-05-27T11:30:41Z
dc.date.issued2013-09-12
dc.description.abstractChronic inflammatory processes close to bone often lead to loss of bone in diseases such as rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is mainly due to local formation of bone resorbing osteoclasts which degrade bone without any subsequent coupling to new bone formation. Crucial for osteoclastogenesis is stimulation of mononuclear osteoclast progenitors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) which induces their differentiation along the osteoclastic lineage and the fusion to mature, multinucleated osteoclasts. M-CSF and RANKL are produced by osteoblasts/ osteocytes and by synovial and periodontal fibroblasts and the expression is regulated by pro- and anti-inflammatory cytokines. These cytokines also regulate osteoclastic differentiation by direct effects on the progenitor cells. In the present overview, we introduce the basic concepts of osteoclast progenitor cell differentiation and summarize the current knowledge on cytokines stimulating and inhibiting osteoclastogenesis by direct and indirect mechanisms. © Informa Healthcare USA, Inc.en
dc.description.affiliationDepartment of Physiology and Pathology Araraquara School of Dentistry Univ. Estadual Paulista-UNESP, Araraquara
dc.description.affiliationDepartment of Molecular Periodontology Umeå University, SE- 901 87 Umeå
dc.description.affiliationCentre for Bone and Arthritis Research at Institute of Medicine Sahlgrenska Academy at University of Gothenburg, Gothenburg
dc.description.affiliationUnespDepartment of Physiology and Pathology Araraquara School of Dentistry Univ. Estadual Paulista-UNESP, Araraquara
dc.format.extent555-622
dc.identifierhttp://dx.doi.org/10.3109/08820139.2013.822766
dc.identifier.citationImmunological Investigations, v. 42, n. 7, p. 555-622, 2013.
dc.identifier.doi10.3109/08820139.2013.822766
dc.identifier.issn0882-0139
dc.identifier.issn1532-4311
dc.identifier.scopus2-s2.0-84883565582
dc.identifier.urihttp://hdl.handle.net/11449/76551
dc.identifier.wosWOS:000324268300006
dc.language.isoeng
dc.relation.ispartofImmunological Investigations
dc.relation.ispartofjcr2.588
dc.relation.ispartofsjr0,740
dc.relation.ispartofsjr0,740
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBone loss
dc.subjectCytokines
dc.subjectInflammation
dc.subjectOsteoclasts
dc.subjectcardiotrophin 1
dc.subjectCD11b antigen
dc.subjectcolony stimulating factor 1
dc.subjectcytokine
dc.subjectinterferon
dc.subjectinterleukin 1
dc.subjectinterleukin 10
dc.subjectinterleukin 11
dc.subjectinterleukin 12
dc.subjectinterleukin 13
dc.subjectinterleukin 15
dc.subjectinterleukin 17
dc.subjectinterleukin 18
dc.subjectinterleukin 20
dc.subjectinterleukin 21
dc.subjectinterleukin 23
dc.subjectinterleukin 27
dc.subjectinterleukin 32
dc.subjectinterleukin 33
dc.subjectinterleukin 34
dc.subjectinterleukin 4
dc.subjectinterleukin 6
dc.subjectinterleukin 7
dc.subjectinterleukin 8
dc.subjectleukemia inhibitory factor
dc.subjectoncostatin M
dc.subjectosteoclast differentiation factor
dc.subjectsphingosine 1 phosphate
dc.subjectsphingosine kinase 1
dc.subjecttumor necrosis factor alpha
dc.subjectunclassified drug
dc.subjectalveolar bone
dc.subjectbone remodeling
dc.subjectcell differentiation
dc.subjectcytokine response
dc.subjectfibroblast
dc.subjecthuman
dc.subjectimmunostimulation
dc.subjectinflammatory disease
dc.subjectnonhuman
dc.subjectosteoblast
dc.subjectosteoclast
dc.subjectosteoclastogenesis
dc.subjectosteocyte
dc.subjectosteolysis
dc.subjectosteosclerosis
dc.subjectperiodontal disease
dc.subjectperiodontitis
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectrheumatoid arthritis
dc.subjectsignal transduction
dc.subjectstem cell
dc.subjecttooth pulp
dc.titleThe role of cytokines in inflammatory bone lossen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
unesp.author.orcid0000-0001-7266-6061[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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