Osseous Flap of Galea and Periosteum Filled with Mesenchymal Stem Cells, Platelet-Rich Plasma, Bone Dust, and Hyaluronic Acid

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dc.contributor.authorBrock, Ryane Schmidt
dc.contributor.authorViterbo, Fausto
dc.contributor.authorDeffune, Elenice
dc.contributor.authorDomingues, Maria Aparecida Custodio
dc.contributor.authorMamprim, Maria Jaqueline
dc.contributor.authorPaschoalinotte, Eloisa Elena [UNESP]
dc.contributor.institutionMedical School of Botucatu
dc.contributor.institutionPlastic and Reconstructive Surgery Division
dc.contributor.institutionHemotheraphy Department
dc.contributor.institutionBotucatu School of Medicine
dc.contributor.institutionBotucatu School of Veterinary Medicine and Animal Science
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:23:37Z
dc.date.available2018-12-11T17:23:37Z
dc.date.issued2017-10-01
dc.description.abstractReconstructive surgery to craniofacial deformities caused by tumor ressections, traumas or congenital malformation are frequent in medicine practice. It aims to provide the patients with better quality of life and functional improvement of speech, breathing, chewing, and swallowing. Many are the techniques described in the literature to recover bone defects. This study evaluated a vascularized galeal and periosteum flap in rabbits, which could possibly substitute the bone graft in reconstructive surgery, especially for facial defects. It involved rabbits, divided into 12 groups, submitted to a surgical procedure to construct the galea and periosteum cranial flap filled with fragments of cranial bone, platelet-rich plasma, mesenchimal stem cells, and hyaluronic acid. The evaluation methods included image examinations and histological analysis. The results demonstrated bone formation with the use of platelet-rich plasma, mesenchimal stem cells, and bone fragments. The use of several enrichment materials of osseous cellular stimulation improved the quality and bone tissue organization. The more enrichment factor used, the better the tissue quality result was. Much research should be done to improve the methods and to analyze if results in human have the same bone formation as it happened in rabbits.en
dc.description.affiliationPostgraduate Program in General Surgery Basis Medical School of Botucatu
dc.description.affiliationPlastic and Reconstructive Surgery Division Department of Surgery
dc.description.affiliationHemotheraphy Department
dc.description.affiliationPathology Department Botucatu School of Medicine
dc.description.affiliationImage and Diagnosis Department Botucatu School of Veterinary Medicine and Animal Science
dc.description.affiliationResearch Support Group Botucatu School of Medicine UNESP
dc.description.affiliationUnespResearch Support Group Botucatu School of Medicine UNESP
dc.format.extent1654-1660
dc.identifierhttp://dx.doi.org/10.1097/SCS.0000000000003775
dc.identifier.citationJournal of Craniofacial Surgery, v. 28, n. 7, p. 1654-1660, 2017.
dc.identifier.doi10.1097/SCS.0000000000003775
dc.identifier.issn1536-3732
dc.identifier.issn1049-2275
dc.identifier.lattes0585723113037140
dc.identifier.lattes8854318602850671
dc.identifier.scopus2-s2.0-85030673159
dc.identifier.urihttp://hdl.handle.net/11449/177045
dc.language.isoeng
dc.relation.ispartofJournal of Craniofacial Surgery
dc.relation.ispartofsjr0,448
dc.relation.ispartofsjr0,448
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBone
dc.subjectcraniofacial malformation
dc.subjectmesenchymal stem cell
dc.subjectplatelet-rich plasma
dc.subjectreconstruction
dc.titleOsseous Flap of Galea and Periosteum Filled with Mesenchymal Stem Cells, Platelet-Rich Plasma, Bone Dust, and Hyaluronic Aciden
dc.typeArtigo
unesp.advisor.lattes0585723113037140
unesp.author.lattes8854318602850671

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