Effects of ovariectomy on the inputs from the medial nucleus of the amygdala to the ventromedial nucleus of the hypothalamus in young adult rats

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dc.contributor.authorGobbo, Denise Ribeiro
dc.contributor.authorPereira, Lais da Silva
dc.contributor.authorPacheco Ferreira, Jozelia Gomes
dc.contributor.authorCastro Horta-Junior, Jose Anchieta de [UNESP]
dc.contributor.authorBittencourt, Jackson Cioni
dc.contributor.authorSa, Susana Isabel
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Porto
dc.date.accessioned2021-06-25T15:00:50Z
dc.date.available2021-06-25T15:00:50Z
dc.date.issued2021-02-16
dc.description.abstractDuring puberty, sexual hormones induce crucial changes in neural circuit organization, leading to significant sexual dimorphism in adult behaviours. The ventrolateral division of the ventromedial nucleus of the hypothalamus (VMHyl) is the major neural site controlling the receptive component of female sexual behaviour, which is dependent on ovarian hormones. The inputs to the VMHyl, originating from the medial nucleus of the amygdala (MeA), transmit essential information to trigger such behaviour. In this study, we investigated the projection pattern of the MeA to the VMHyl in ovariectomized rats at early puberty. Six-week-old SpragueDawley rats were ovariectomized (OVX) and, upon reaching 90 days of age, were subjected to iontophoretic injections of the neuronal anterograde tracer Phaseolus vulgaris leucoagglutinin into the MeA. Projections from the MeA to the VMHyl and to other structures included in the neural circuit responsible for female sexual behaviour were analysed in the Control and OVX groups. The results of the semi-quantitative analysis showed that penpubertal ovariectomy reduced the density of intra-amygdalar fibres. The stereological estimates, however, failed to find changes in the organization of the terminal fields of nerve fibres from the MeA to the VMHyl in the adult. The present data show that ovariectomized rats during the peripubertal phase did not undergo significant changes in MeA fibres reaching the VMHyl; however, they suggest a possible effect of ovariectomy on MeA connectivity under amygdalar subnuclei.en
dc.description.affiliationUniv Sao Paulo, Inst Ciencias Biomed, Dept Anat, Lab Neuroanat Quim, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Psicol Nucleo Neurociencias & Comportamento, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Porto, Fac Med, Dept Biomed, Unit Anat, Porto, Portugal
dc.description.affiliationUniv Porto, Fac Med, Ctr Hlth Technol & Serv Res, CINTESIS, Porto, Portugal
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Anat, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipNational Funds through the FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS
dc.description.sponsorshipIdFAPESP: 2010/52068-0
dc.description.sponsorshipIdFAPESP: 2016/02224-1
dc.description.sponsorshipIdFAPESP: 2015/05990-4
dc.description.sponsorshipIdCAPES: 848/15
dc.description.sponsorshipIdCNPq: 426378/2016-4
dc.description.sponsorshipIdNational Funds through the FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS: UID/IC/4255/2013
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2021.135657
dc.identifier.citationNeuroscience Letters. Clare: Elsevier Ireland Ltd, v. 746, 11 p., 2021.
dc.identifier.doi10.1016/j.neulet.2021.135657
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/11449/210187
dc.identifier.wosWOS:000636460700008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.sourceWeb of Science
dc.subjectPhaseolus vulgaris leucoagglutinin
dc.subjectThree-dimensional reconstruction
dc.subjectFemale sexual behaviour
dc.subjectOvarian hormones
dc.subjectPeri pubertal period
dc.subjectNeural circuits
dc.titleEffects of ovariectomy on the inputs from the medial nucleus of the amygdala to the ventromedial nucleus of the hypothalamus in young adult ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-7033-0975[1]
unesp.author.orcid0000-0002-8908-6474[5]

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