Permethrin chronic exposure alters motor coordination in rats: Effect of calcium supplementation and amlodipine

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dc.contributor.authorGodinho, A. F. [UNESP]
dc.contributor.authorStanzani, S. L. [UNESP]
dc.contributor.authorFerreira, F. C. [UNESP]
dc.contributor.authorBraga, T. C. [UNESP]
dc.contributor.authorSilva, M. C. [UNESP]
dc.contributor.authorChaguri, J. L. [UNESP]
dc.contributor.authorDias-Junior, C. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:36Z
dc.date.available2014-12-03T13:11:36Z
dc.date.issued2014-03-01
dc.description.abstractRecently was observed that pyrethroids decrease motor coordination and that calcium channels can be important targets for this effect. To contribute with this observation, this work studied the motor coordination and exploration (using hole-board apparatus), and locomotion (using open-field apparatus) of rats exposed to following treatments: permethrin (PM), PM plus calcium gluconate (CG) and PM plus amlodipine (AML). The results obtained show that CG or AML alone not changed the motor coordination while PM decreases it. CG kept the effect of permethrin; AML, however, decreased the values of permethrin to the control. Locomotor activity and exploration, which could confound results of motor coordination, were not modified by treatments. The concentration of PM in brain tissue was increased by the CG and AML. The neurosomatic index (weight brain/body weight) was increased by the PM and PM + CG. In conclusion, the combined results here obtained indicates that the calcium ion and the channels in which it is involved can be important targets for the toxic effect of pyrethroid insecticide permethrin on motor nerve activity of rats. (c) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, UNESP, Ctr Assistencia Toxicol CEATOX, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, UNESP, Ctr Assistencia Toxicol CEATOX, BR-18618000 Botucatu, SP, Brazil
dc.format.extent878-884
dc.identifierhttp://dx.doi.org/10.1016/j.etap.2014.02.017
dc.identifier.citationEnvironmental Toxicology And Pharmacology. Amsterdam: Elsevier Science Bv, v. 37, n. 2, p. 878-884, 2014.
dc.identifier.doi10.1016/j.etap.2014.02.017
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/11449/113326
dc.identifier.wosWOS:000335636600044
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.relation.ispartofjcr2.776
dc.relation.ispartofsjr0,813
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPermethrinen
dc.subjectMotor coordinationen
dc.subjectCalciumen
dc.subjectBehavioren
dc.subjectAmlodipineen
dc.subjectRaten
dc.titlePermethrin chronic exposure alters motor coordination in rats: Effect of calcium supplementation and amlodipineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes9719891659222257[1]
unesp.author.lattes6296664642422599[7]
unesp.author.orcid0000-0002-2832-8919[1]
unesp.author.orcid0000-0002-0348-6144[7]

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