Effect of maternal true combined endodontic-periodontal lesion on insulin and inflammatory pathway in adult offspring

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dc.contributor.authorBelardi, Bianca Elvira [UNESP]
dc.contributor.authorMattera, Maria Sara de Lima Coutinho [UNESP]
dc.contributor.authorTsosura, Thaís Verônica Saori [UNESP]
dc.contributor.authordos Santos, Rodrigo Martins [UNESP]
dc.contributor.authorCantiga-Silva, Cristiane [UNESP]
dc.contributor.authorTavares Ângelo Cintra, Luciano [UNESP]
dc.contributor.authorChiba, Fernando Yamamoto [UNESP]
dc.contributor.authorBravo, Lara Teschi [UNESP]
dc.contributor.authorCarvalho, Nubia Ramos [UNESP]
dc.contributor.authorCarnevali, Ana Carolina Nascimento [UNESP]
dc.contributor.authorde Oliveira, Renan Akira Fujii [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorMatsushita, Doris Hissako [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T14:13:04Z
dc.date.available2023-07-29T14:13:04Z
dc.date.issued2023-04-01
dc.description.abstractBackground: Maternal periodontal disease (PED) and apical periodontitis (AP) are associated insulin resistance (IR), increased tumor necrosis factor-α (TNF-α) levels, and alterations in insulin signaling (IS) in the gastrocnemius muscle (GM) of adult offspring. TNF-α stimulates I kappa B kinase (IKK) and c-Jun N-terminal protein kinase (JNK), resulting in IS attenuation. However, studies that investigated the maternal true endodontic-periodontal lesion (EPL) in offspring are scarce, and in this case, the impact could be even higher. This study aimed to evaluate the effects of EPL on the IR, IS, and inflammatory pathways on the offspring GM. Methods: Female Wistar rats were distributed into control, AP, PED, and EPL groups. After 30 days of oral inflammation induction, rats from all groups were allowed to mate with healthy rats. The body weight of the offspring was assessed from birth to 75 days of age. After 75 days, the following measurements were performed: glycemia, insulinemia, IR, TNF-α content, and IKKα/β, JNK, pp185 (Tyr), and IRS-1 (Ser) phosphorylation status in the GM. Results: Maternal PED and EPL were associated with low birth weights. All maternal oral inflammations promoted IR and IS impairment in the GM and only maternal PED and EPL caused an increase in TNF-α content and IKKα/β phosphorylation status in the GM of offspring. The offspring of the rats with EPL group showed worsening of metabolic changes when compared with offspring of rats with AP or PED. Conclusion: Association of maternal AP and PED promoted a more pronounced worsening in the health of the adult offspring.en
dc.description.affiliationPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis Department of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationInstitute of Biosciences Botucatu Brazil and Department of Basic Sciences Division of Histology School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis Department of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Biosciences Botucatu Brazil and Department of Basic Sciences Division of Histology School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)
dc.format.extent487-497
dc.identifierhttp://dx.doi.org/10.1002/JPER.22-0139
dc.identifier.citationJournal of Periodontology, v. 94, n. 4, p. 487-497, 2023.
dc.identifier.doi10.1002/JPER.22-0139
dc.identifier.issn0022-3492
dc.identifier.scopus2-s2.0-85138755521
dc.identifier.urihttp://hdl.handle.net/11449/249202
dc.language.isoeng
dc.relation.ispartofJournal of Periodontology
dc.sourceScopus
dc.subjectapical periodontitis
dc.subjectinsulin resistance
dc.subjectlow birth weight
dc.subjectperiodontal diseases
dc.subjecttumor necrosis factor-alpha
dc.titleEffect of maternal true combined endodontic-periodontal lesion on insulin and inflammatory pathway in adult offspringen
dc.typeArtigo
unesp.author.orcid0000-0002-5564-8256[1]
unesp.author.orcid0000-0003-2288-708X[2]
unesp.author.orcid0000-0003-1708-4071[3]
unesp.author.orcid0000-0002-5122-275X[4]
unesp.author.orcid0000-0003-4313-7149[5]
unesp.author.orcid0000-0003-2348-7846[6]
unesp.author.orcid0000-0003-4406-405X[7]
unesp.author.orcid0000-0001-9985-6164[8]
unesp.author.orcid0000-0003-0874-2714[10]
unesp.author.orcid0000-0003-1479-0413[11]
unesp.author.orcid0000-0003-4859-0583[12]
unesp.author.orcid0000-0003-3753-229X[13]

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