Early embryo morphokinetics is a better predictor of post-ICSI live birth than embryo morphology: Speed is more important than beauty at the cleavage stage

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dc.contributor.authorBartolacci, Alessandro
dc.contributor.authorDal Canto, Mariabeatrice
dc.contributor.authorGuglielmo, Maria Cristina
dc.contributor.authorMura, Laura
dc.contributor.authorBrigante, Claudio
dc.contributor.authorMignini Renzini, Mario
dc.contributor.authorBuratini, Jose [UNESP]
dc.contributor.institutionIstituti Clinici Zucchi
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T04:26:35Z
dc.date.available2022-05-01T04:26:35Z
dc.date.issued2021-01-01
dc.description.abstractGiven the importance of embryo developmental competence assessment in reproductive medicine and biology, the aim of this study was to compare the performance of fertilization and cleavage morphokinetics with embryo morphology to predict post-ICSI live birth. Data from embryos cultured in a time-lapse microscopy (TLM) incubator and with known live birth outcomes (LB: embryos achieving live birth, n = 168; NLB: embryos not achieving live birth, n = 1633) were used to generate receiver operating characteristic (ROC) curves based on morphokinetic or morphological scores, and the respective areas under the curve (AUC) were compared. The association between live birth and 12 combinations of four morphokinetic quality degrees (A-D) with three morphological quality degrees (A-C) was assessed using multivariate analysis. Morphokinetic parameters from tPNa to t8 were reached earlier in LB compared with NLB embryos. The ROC curve analysis indicated that morphokinetic information is more accurate than conventional morphology to predict live birth [AUC = 0.64 (95% CI 0.58-0.70) versus AUC = 0.58 (95% CI 0.51-0.65)]. The multivariate analysis was in line with AUCs, revealing that embryos with poor morphokinetics, independently of their morphology, provide lower live birth rates (P < 0.001). A considerable percentage of embryos with top morphology presented poor morphokinetics (20.10%), accompanied by a severely reduced live birth rate in comparison with embryos with top morphology and morphokinetics (P < 0.001). In conclusion, TLM-derived early morphokinetic parameters were more predictive of live-birth achievement following ICSI than conventional morphology.en
dc.description.affiliationBiogenesi Reproductive Medicine Centre Istituti Clinici Zucchi, Via Zucchi, 24
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University
dc.identifierhttp://dx.doi.org/10.1017/S0967199421000253
dc.identifier.citationZygote.
dc.identifier.doi10.1017/S0967199421000253
dc.identifier.issn1469-8730
dc.identifier.issn0967-1994
dc.identifier.scopus2-s2.0-85105192840
dc.identifier.urihttp://hdl.handle.net/11449/233124
dc.language.isoeng
dc.relation.ispartofZygote
dc.sourceScopus
dc.subjectICSI
dc.subjectKeywords:
dc.subjectLive birth
dc.subjectMorphokinetics
dc.subjectMorphology
dc.subjectTime-lapse microscopy
dc.titleEarly embryo morphokinetics is a better predictor of post-ICSI live birth than embryo morphology: Speed is more important than beauty at the cleavage stageen
dc.typeArtigo
unesp.author.orcid0000-0001-5698-5513[1]

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