Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant

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dc.contributor.authorEleuterio, Nibia Mariana [UNESP]
dc.contributor.authorPalei, Ana C. T.
dc.contributor.authorMachado, Jackeline S. Rangel
dc.contributor.authorTanus-Santos, Jose E.
dc.contributor.authorCavalli, Ricardo C.
dc.contributor.authorSandrim, Valeria C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-12-07T15:32:46Z
dc.date.available2015-12-07T15:32:46Z
dc.date.issued2015
dc.description.abstractThe aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them. A total of 105 pregnant women with pre-pregnancy body mass index (BMI) values ⩽ 30 kg/m(2) were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs. Adiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0.05). In addition there were positive correlations between adiponectin and MMP2 (r = 0.33; P = 0.03) and adiponectin and TIMP2 (r = 0.33; P = 0.03) in PE group, but not in HP. Our findings show that adiponectin, leptin, MMP2, TIMP1 and TIMP2 levels are increased in PE and adiponectin may contribute to higher levels of MMP2 and TIMP2 in this disease.en
dc.description.affiliationDepartment of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil
dc.description.affiliationDepartment of Pharmacology, Faculty of Medicinal Sciences, University of Campinas, State University of Campinas, Campinas/SP, Brazil
dc.description.affiliationDepartment of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto/SP, Brazil
dc.description.affiliationDepartment of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto/SP, Brazil.
dc.description.affiliationDepartment of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil
dc.description.affiliationUnespDepartment of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil
dc.description.affiliationUnespDepartment of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent205-208
dc.identifierhttp://dx.doi.org/10.1016/j.preghy.2015.03.001
dc.identifier.citationPregnancy Hypertension, v. 5, n. 2, p. 205-208, 2015.
dc.identifier.doi10.1016/j.preghy.2015.03.001
dc.identifier.issn2210-7797
dc.identifier.pubmed25943646
dc.identifier.urihttp://hdl.handle.net/11449/131222
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofPregnancy Hypertension
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAdiponectinen
dc.subjectLeptinen
dc.subjectMetalloproteinase (mmp)-2 and (mmp)-9en
dc.subjectPreeclampsiaen
dc.subjectTissue inhibitor of metalloproteinase (timp)-1 and (timp)-2en
dc.titlePositive correlations between circulating adiponectin and MMP2 in preeclampsia pregnanten
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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