Curcurnin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1,-3 and p38 MAPK

Página do item simplificado
dc.contributor.authorGuimaraes, Morgana Rodrigues [UNESP]
dc.contributor.authorManzoli Leite, Fabio Renato [UNESP]
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.authorKirkwood, Keith Lough
dc.contributor.authorRossa, Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMed Univ S Carolina
dc.date.accessioned2014-12-03T13:10:46Z
dc.date.available2014-12-03T13:10:46Z
dc.date.issued2013-10-01
dc.description.abstractCurcumin is the active compound in the extract of Curcuma longa rhizomes with anti-inflammatory properties mediated by inhibition of intracellular signalling. SOCS and MAP-Kinases are involved in the signalling events controlling the expression of IL-6, TNF-alpha and PGE(2), which have important roles on chronic inflammatory diseases. The aim was to assess if these pathways are involved in curcumin-mediated effects on LPS-induced expression of these cytokines in macrophages. RAW 264.7 murine macrophages were stimulated with Escherichia coli LPS in the presence and absence of non-cytotoxic concentrations of curcumin. Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation. In conclusion, curcumin potently inhibits expression of LPS-induced inflammatory cytokines in macrophages via mechanisms that involve modulation of expression and activity of SOCS-1 and SOCS-3 and of p38 MAPK. (C) 2013 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Diag & Surg, Fac Odontol Araraquara, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Physiol & Pathol, Fac Odontol Araraquara, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationMed Univ S Carolina, Coll Dent Med, Dept Craniofacial Biol, Charleston, SC USA
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Diag & Surg, Fac Odontol Araraquara, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Physiol & Pathol, Fac Odontol Araraquara, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipBrazilian Ministry of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipBrazilian Ministry of Education. National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH)
dc.description.sponsorshipIdCAPES: 4638-05
dc.description.sponsorshipIdBrazilian Ministry of Education. National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH)1R01DE018290
dc.description.sponsorshipIdBrazilian Ministry of Education. National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH)P30GM103331-02
dc.format.extent1309-1317
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2013.07.005
dc.identifier.citationArchives Of Oral Biology. Oxford: Pergamon-elsevier Science Ltd, v. 58, n. 10, p. 1309-1317, 2013.
dc.identifier.doi10.1016/j.archoralbio.2013.07.005
dc.identifier.issn0003-9969
dc.identifier.lattes2640929291808415
dc.identifier.urihttp://hdl.handle.net/11449/112511
dc.identifier.wosWOS:000325236600006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCurcuminen
dc.subjectInnate immunityen
dc.subjectCell signallingen
dc.subjectCytokinesen
dc.subjectNF-kappa Ben
dc.subjectMAPKen
dc.subjectSOCSen
dc.titleCurcurnin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1,-3 and p38 MAPKen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2640929291808415
unesp.author.lattes7634063102292261[5]
unesp.author.orcid0000-0003-1705-5481[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Coleções

Artigos - Diagnóstico e Cirurgia - FOAR
Artigos - Fisiologia e Patologia - FOAR