Synchronization and propagation of global sleep spindles

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dc.contributor.authorDe Souza, Rafael Toledo Fernandes [UNESP]
dc.contributor.authorGerhardt, Günther Johannes Lewczuk
dc.contributor.authorSchönwald, Suzana Veiga
dc.contributor.authorRybarczyk-Filho, José Luiz [UNESP]
dc.contributor.authorLemke, Ney [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Caxias do Sul
dc.contributor.institutionNeurology and Pulmonology Sections
dc.date.accessioned2018-12-11T17:27:46Z
dc.date.available2018-12-11T17:27:46Z
dc.date.issued2016-03-01
dc.description.abstractSleep spindles occur thousands of times during normal sleep and can be easily detected by visual inspection of EEG signals. These characteristics make spindles one of the most studied EEG structures in mammalian sleep. In this work we considered global spindles, which are spindles that are observed simultaneously in all EEG channels.We propose a methodology that investigates both the signal envelope and phase/frequency of each global spindle. By analysing the global spindle phase we showed that 90% of spindles synchronize with an average latency time of 0.1 s. We also measured the frequency modulation (chirp) of global spindles and found that global spindle chirp and synchronization are not correlated. By investigating the signal envelopes and implementing a homogeneous and isotropic propagation model, we could estimate both the signal origin and velocity in global spindles. Our results indicate that this simple and non-invasive approach could determine with reasonable precision the spindle origin, and allowed us to estimate a signal speed of 0.12 m/s. Finally, we consider whether synchronization might be useful as a non-invasive diagnostic tool.en
dc.description.affiliationDepartamento de Física e Biofísica UNESP - Univ. Estadual Paulista
dc.description.affiliationDepartamento de Física e Química Universidade de Caxias do Sul
dc.description.affiliationHospital de Clínicas de Porto Alegre (HCPA) Neurology and Pulmonology Sections
dc.description.affiliationUnespDepartamento de Física e Biofísica UNESP - Univ. Estadual Paulista
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0151369
dc.identifier.citationPLoS ONE, v. 11, n. 3, 2016.
dc.identifier.doi10.1371/journal.pone.0151369
dc.identifier.file2-s2.0-84962604306.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes7977035910952141
dc.identifier.scopus2-s2.0-84962604306
dc.identifier.urihttp://hdl.handle.net/11449/177934
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleSynchronization and propagation of global sleep spindlesen
dc.typeArtigo
unesp.author.lattes7977035910952141

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Artigos - Física e Biofísica - IBB