Intravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two cases

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dc.contributor.authorMachado, Gisele Fabrino [UNESP]
dc.contributor.authorCastro, Márcio B.
dc.contributor.authorMelo, Guilherme D. [UNESP]
dc.contributor.authorFerreira, Wagner Luis [UNESP]
dc.contributor.authorAylon, Eliana G.
dc.contributor.authorAlessi, Antonio C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUNIFRAN - Univ de Franca
dc.date.accessioned2014-05-27T11:25:51Z
dc.date.available2014-05-27T11:25:51Z
dc.date.issued2011-04-18
dc.description.abstractWe report here two postmortem cases of dogs with intravascular lymphomatosis affecting the central nervous system. Intravascular lymphomatosis is represented by an exclusively intravascular proliferation of neoplastic lymphoid cells. To characterize the origin of the neoplastic cells, we have proceeded with immunohistochemical analysis to identify B and T lymphocytes and endothelial cells. The results showed predominance of cells from the T cell lineage, and no evidence of B cell origin was found. Few cells from one dog also exhibited cytoplasmatic staining for vimentin and Von Willebrand factor. Although in one case some immunophenotype diversity was observed, the massive presence of CD3 positive cells confirmed these neoplasms as intravascular lymphomatosis of T cell origin.en
dc.description.affiliationDepartamento de Clínica, Cirurgia e Reprodução Animal FMV-Universidade Estadual Paulista (UNESP), Araçatuba, SP
dc.description.affiliationDepartamento de Anatomofisiologia e Reprodução FAV-UNB - Univ de Brasília, Brasília, DF
dc.description.affiliationUNIFRAN - Univ de Franca, Franca, SP
dc.description.affiliationDepartamento de Patologia Veterinária FCAV-Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.description.affiliationUnespDepartamento de Clínica, Cirurgia e Reprodução Animal FMV-Universidade Estadual Paulista (UNESP), Araçatuba, SP
dc.description.affiliationUnespDepartamento de Patologia Veterinária FCAV-Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.format.extent47-51
dc.identifierhttp://www.abpv.vet.br/upload/documentos/DOWNLOAD-FULL-ARTICLE-09-20881_2011_3_16_8_11.pdf
dc.identifier.citationBrazilian Journal of Veterinary Pathology, v. 4, n. 1, p. 47-51, 2011.
dc.identifier.issn1983-0246
dc.identifier.lattes0310405558125634
dc.identifier.lattes7515150042015756
dc.identifier.scopus2-s2.0-79953841993
dc.identifier.urihttp://hdl.handle.net/11449/72385
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Veterinary Pathology
dc.relation.ispartofsjr0,162
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCell marker
dc.subjectImmunohistochemistry
dc.subjectLymphoproliferative disorder
dc.subjectNeoplasia
dc.subjectNeuropathology
dc.subjectT cell
dc.subjectCanis familiaris
dc.titleIntravascular lymphomatosis in the central nervous system of dogs: Immunohistochemical investigation in two casesen
dc.typeArtigo
dcterms.licensehttp://www.abpv.vet.br/paginas_site/default.asp?P=BJVP&PAG_SEQ=4282
unesp.author.lattes0310405558125634
unesp.author.lattes7515150042015756
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Clínica, Cirurgia e Reprodução Animal - FMVA
Artigos - Patologia Veterinária - FCAV