Simple GFAAS Method for Determination of Pb, As, and Cd in Cannabidiol Extracts Used for Therapeutic Purposes

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dc.contributor.authorNascimento, Patricia A.
dc.contributor.authorSchultz, Juliana
dc.contributor.authorGonzalez, Mario H. [UNESP]
dc.contributor.authorOliveira, Andrea
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T19:54:47Z
dc.date.available2020-12-10T19:54:47Z
dc.date.issued2020-05-01
dc.description.abstractCannabis sativa has many promising medicinal applications for the mitigation, or even cure, of chronic diseases. The high bioaccumulation potential of C. sativa enables its use for the phytoremediation and detoxification of soil, may increase the levels of inorganic elements in products such as cannabidiol (CBD) extracts being necessary the evaluation/monitoring of the level of inorganic components, mainly the toxic species in these formulations. An analytical method employing graphite furnace atomic absorption spectrometry (GFAAS) was developed for the quantification of Pb, As, and Cd in commercial CBD extracts and homemade samples. The alkaline solubilization was employed in agreement with the external analytical curve, in a robust method. The limits of quantification were 0.26 (Pb), 0.067 (As), and 0.011 mu g g(-1) (Cd), with satisfactory accuracy (80-120%) and relative standard deviation (RSE)) values < 7%. The CBD extracts presented levels of Pb. As and Cd below the maximum limits established by regulatory agencies.en
dc.description.affiliationUniv Fed Parana UFPR, Dept Quim, BR-81531980 Curitiba, Parana, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Quim & Ciencias Ambientais, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Quim & Ciencias Ambientais, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2017/18531-3
dc.description.sponsorshipIdFAPESP: 2017/13230-5
dc.description.sponsorshipIdFAPESP: 2017/09520-8
dc.description.sponsorshipIdFAPESP: 2013/23886-4
dc.description.sponsorshipIdFAPESP: 2015/08873-9
dc.format.extent894-903
dc.identifierhttp://dx.doi.org/10.21577/0103-5053.20190252
dc.identifier.citationJournal Of The Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, v. 31, n. 5, p. 894-903, 2020.
dc.identifier.doi10.21577/0103-5053.20190252
dc.identifier.fileS0103-50532020000500894.pdf
dc.identifier.issn0103-5053
dc.identifier.scieloS0103-50532020000500894
dc.identifier.urihttp://hdl.handle.net/11449/196742
dc.identifier.wosWOS:000522795800004
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal Of The Brazilian Chemical Society
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCannabis saliva L.
dc.subjectmedicinal plant
dc.subjectinorganic quantification
dc.subjecttoxic elements
dc.subjectalkaline solubilization
dc.titleSimple GFAAS Method for Determination of Pb, As, and Cd in Cannabidiol Extracts Used for Therapeutic Purposesen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica

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Artigos - Química e Ciências Ambientais - IBILCE