Cervicovaginal Levels of Human β-Defensin 1, 2, 3, and 4 of Reproductive-Aged Women with Chlamydia trachomatis Infection

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dc.contributor.authorNoda-Nicolau, Nathália Mayumi [UNESP]
dc.contributor.authorBastos, Larissa Brito [UNESP]
dc.contributor.authorBolpetti, Aline Nascimento [UNESP]
dc.contributor.authorPinto, Gabriel Vitor Silva [UNESP]
dc.contributor.authorMarcolino, Larissa Doddi [UNESP]
dc.contributor.authorMarconi, Camila [UNESP]
dc.contributor.authorFerreira, Carolina Sanitá Tafner [UNESP]
dc.contributor.authorPolettini, Jossimara
dc.contributor.authorVieira, Eliane Passarelli [UNESP]
dc.contributor.authorDa Silva, Márcia Guimarães [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionPresidente Prudente
dc.date.accessioned2018-12-11T17:11:35Z
dc.date.available2018-12-11T17:11:35Z
dc.date.issued2017-07-01
dc.description.abstractObjective This study included women attending primary health care units in Botucatu, São Paulo, Brazil, to assess the cervicovaginal levels of human β-defensin (hBD) 1, 2, 3, and 4 during Chlamydia trachomatis infection. Patients and Methods Cervicovaginal samples were collected for Pap testing and assessing the presence of infection by C. trachomatis, human papillomavirus, Neisseria gonorrhoeae, and Trichomonas vaginalis. Vaginal smears were taken to evaluate local microbiota. Human β-defensin levels were determined using enzyme-linked immunosorbent assay in cervicovaginal fluid samples. Seventy-four women with normal vaginal microbiota and no evidence of infection were included in hBD quantification assays; 37 tested positive for C. trachomatis and 37 were negative. Statistical analysis was performed using Mann-Whitney U test. Results Women positive for C. trachomatis had significantly lower cervicovaginal hBD-1, hBD-2, and hBD-3 compared with those who tested negative (hBD-1: 0 pg/mL [0-2.1] vs 1.6 pg/mL [0-2.4], p <.0001; hBD-2: 0 pg/mL [0-3.9] vs 0.61 pg/mL [0-8.9], p =.0097; and hBD-3: 0 pg/mL [0-4.3] vs 0.28 pg/mL [0-8.4], p =.0076). Human β-defensin 4 was not detected. Conclusions Lower levels of hBD-1, hBD-2, and hBD-3 in cervicovaginal fluid were detected in the presence of C. trachomatis infection.en
dc.description.affiliationDepartment of Pathology Botucatu Medical School UNESP Universidade Estadual Paulista
dc.description.affiliationDepartment of Basic Pathology Setor de Ciências Biológicas UFPR Universidade Federal Do Paraná
dc.description.affiliationUniversity of Western São Paulo (UNOESTE) Presidente Prudente
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School UNESP Universidade Estadual Paulista
dc.format.extent189-192
dc.identifierhttp://dx.doi.org/10.1097/LGT.0000000000000315
dc.identifier.citationJournal of Lower Genital Tract Disease, v. 21, n. 3, p. 189-192, 2017.
dc.identifier.doi10.1097/LGT.0000000000000315
dc.identifier.issn1526-0976
dc.identifier.issn1089-2591
dc.identifier.scopus2-s2.0-85018807683
dc.identifier.urihttp://hdl.handle.net/11449/174533
dc.language.isoeng
dc.relation.ispartofJournal of Lower Genital Tract Disease
dc.relation.ispartofsjr0,602
dc.relation.ispartofsjr0,602
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectantimicrobial peptides
dc.subjectcervicovaginal fluid
dc.subjectChlamydia trachomatis
dc.subjecthuman β defensins
dc.subjectwomen
dc.titleCervicovaginal Levels of Human β-Defensin 1, 2, 3, and 4 of Reproductive-Aged Women with Chlamydia trachomatis Infectionen
dc.typeArtigo

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