Repercussions of low fructose-drinking water in male rats

Página do item simplificado
dc.contributor.authorMiranda, Carolina Abreu
dc.contributor.authorSchönholzer, Tatiele E.
dc.contributor.authorKlöppel, Eduardo
dc.contributor.authorSinzato, Yuri K. [UNESP]
dc.contributor.authorVolpato, Gustavo T. [UNESP]
dc.contributor.authorDamasceno, Débora C. [UNESP]
dc.contributor.authorCampos, Kleber E.
dc.contributor.institutionAvenida Valdon Varjão
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:18:07Z
dc.date.available2019-10-06T16:18:07Z
dc.date.issued2019-01-01
dc.description.abstractFructose consumption has increased worldwide, and it has been associated with the development of metabolic diseases such as insulin resistance (IR) and steatosis. The aim was to evaluate if lower fructose concentrations may cause pancreatic structural abnormalities, leading to a glucose intolerance without steatosis in male rats. Young male rats orally received 7% fructose solution for 12 weeks. Body weight, food, water, and energy intake were measured. An oral glucose tolerance test (OGTT) was performed. After final experimental period, all rats were anaesthetized and killed. Blood samples were collected for biochemical analyses and organs (liver and pancreas) were processed for morphological analyses. Fructose consumption was not associated with lipid accumulation in liver. However, fructose administration was associated with an increased area under curve from OGTT and an increased percentage of insulin-positive cells, high beta cell mass and reduced pancreatic islet area. Fructose supplementation (7%) did not cause steatosis, but it led to abnormal morphology and function of pancreatic islet cells, contributing for glucose intolerance development. Our findings demonstrate that even low fructose concentrations may cause deleterious effects in animals.en
dc.description.affiliationLaboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva Instituto de Ciências Biológicas e da Saúde Universidade Federal de Mato Grosso/UFMT Avenida Valdon Varjão
dc.description.affiliationLaboratório de Pesquisa Experimental de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu Universidade Estadual Paulista/UNESP, Distrito de Rubião Junior, s/n
dc.description.affiliationUnespLaboratório de Pesquisa Experimental de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu Universidade Estadual Paulista/UNESP, Distrito de Rubião Junior, s/n
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdCAPES: 001
dc.identifierhttp://dx.doi.org/10.1590/0001-3765201920170705
dc.identifier.citationAnais da Academia Brasileira de Ciencias, v. 91, n. 1, 2019.
dc.identifier.doi10.1590/0001-3765201920170705
dc.identifier.fileS0001-37652019000100702.pdf
dc.identifier.issn1678-2690
dc.identifier.issn0001-3765
dc.identifier.scieloS0001-37652019000100702
dc.identifier.scopus2-s2.0-85061856975
dc.identifier.urihttp://hdl.handle.net/11449/188753
dc.language.isoeng
dc.relation.ispartofAnais da Academia Brasileira de Ciencias
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectFructose
dc.subjectGlucose intolerance
dc.subjectIslet pancreatic
dc.subjectSteatosis
dc.titleRepercussions of low fructose-drinking water in male ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-4402-1466[1]

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0001-37652019000100702.pdf
Tamanho:
6.7 MB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Artigos - Ginecologia e Obstetrícia - FMB