Beneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice

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dc.contributor.authorRomualdo, Guilherme Ribeiro [UNESP]
dc.contributor.authorde Souza, Isadora Penedo [UNESP]
dc.contributor.authorde Souza, Lucas Vilhegas [UNESP]
dc.contributor.authorPrata, Gabriel Bacil [UNESP]
dc.contributor.authorFraga-Silva, Thais Fernanda de Campos [UNESP]
dc.contributor.authorSartori, Alexandrina [UNESP]
dc.contributor.authorBorguini, Renata Galhardo
dc.contributor.authorSantiago, Manuela Cristina Pessanha de Araújo
dc.contributor.authorFernandes, Ana Angélica Henrique [UNESP]
dc.contributor.authorCogliati, Bruno
dc.contributor.authorBarbisan, Luís Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2021-06-25T11:09:04Z
dc.date.available2021-06-25T11:09:04Z
dc.date.issued2021-01-01
dc.description.abstractHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-α). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-α levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction.en
dc.description.affiliationSão Paulo State University (UNESP) Biosciences Institute Department of Structural and Functional Biology
dc.description.affiliationSão Paulo State University (UNESP) Biosciences Institute Department of Chemical and Biological Sciences
dc.description.affiliationEmbrapa Food Technology
dc.description.affiliationUniversity of São Paulo (USP) School of Veterinary Medicine and Animal Science Department of Pathology
dc.description.affiliationUnespSão Paulo State University (UNESP) Biosciences Institute Department of Structural and Functional Biology
dc.description.affiliationUnespSão Paulo State University (UNESP) Biosciences Institute Department of Chemical and Biological Sciences
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 2017/17516-0
dc.identifierhttp://dx.doi.org/10.1016/j.foodres.2020.109964
dc.identifier.citationFood Research International, v. 139.
dc.identifier.doi10.1016/j.foodres.2020.109964
dc.identifier.issn1873-7145
dc.identifier.issn0963-9969
dc.identifier.scopus2-s2.0-85097712200
dc.identifier.urihttp://hdl.handle.net/11449/208248
dc.language.isoeng
dc.relation.ispartofFood Research International
dc.sourceScopus
dc.subjectAnthocyanin-rich fruit peels
dc.subjectHepatocarcinogenesis
dc.subjectLiver fibrosis
dc.subjectMyrciaria jaboticaba
dc.subjectMyrtaceae family
dc.subjectSyzygium cumini
dc.subjectSyzygium malaccense
dc.titleBeneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in miceen
dc.typeArtigo

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Artigos - Microbiologia e Imunologia - IBB
Artigos - Morfologia - IBB
Artigos - Química e Bioquímica - IBB