Larvicidal potential of extracts and isolated compounds from Piper cubeba fruits against Aedes aegypti (Diptera: Culicidae) larvae

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dc.contributor.authorGomes, Ana Carolina [UNESP]
dc.contributor.authorBorges, Alexandre
dc.contributor.authorZoca, Daniela Garcia
dc.contributor.authorSilva, Marcio Luís Andrade e
dc.contributor.authorMachado, Aline Rafaela da Silva Rodrigues
dc.contributor.authorMachado, Alex Martins
dc.contributor.authorSantos, Mario F. C.
dc.contributor.authorde Laurentiz, Rosangela da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCentro Universitário–UNIFUNEC
dc.contributor.institutionUniversidade de Franca
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.date.accessioned2023-07-29T13:24:08Z
dc.date.available2023-07-29T13:24:08Z
dc.date.issued2022-01-01
dc.description.abstractAedes aegypti is the primary vector of virus transmission that causes dengue, yellow fever, chikungunya and zika. The primary prevention method has been vector control and synthetic insecticides that can cause environmental side effects. Thus, the work aimed to evaluate the larvicidal potential of extracts and isolated compounds from Piper cubeba against A. aegypti larvae. The larvicidal activity method was executed according to the World Health Organization protocol. The larvae were analyzed by scanning electron microscopy (SEM). Through molecular docking, the action mechanism was investigated. The hydroalcoholic and hexane extracts showed similar larvicidal activity with LC50 of 191.1 μg/mL and 185.84 μg/mL, respectively. Between isolated compounds, hinokinin presented LC50= 97.74 μg/mL. The SEM analysis showed structural damage to the larva’s tegument caused by extracts and isolated compounds. Therefore, the results demonstrate the larvicidal action of hinokinin and extracts, which can lead to the development of new natural larvicides.en
dc.description.affiliationDepartamento de Física e Química Faculdade de Engenharia de Ilha Solteira UNESP–Univ Estadual Paulista, São Paulo
dc.description.affiliationFaculdade de Medicina Centro Universitário–UNIFUNEC, São Paulo
dc.description.affiliationNúcleo de Pesquisa em Ciências Exatas e Tecnológicas Universidade de Franca, São Paulo
dc.description.affiliationLaboratório de Virologia da Universidade Federal de Mato Grosso do Sul–UFMS, Mato Grosso do Sul
dc.description.affiliationDepartamento de Química e Física Centro de Ciências Exatas Naturais e da Saúde Universidade Federal do Espírito Santo Alto Universitário, Espírito Santo
dc.description.affiliationUnespDepartamento de Física e Química Faculdade de Engenharia de Ilha Solteira UNESP–Univ Estadual Paulista, São Paulo
dc.identifierhttp://dx.doi.org/10.1080/14786419.2022.2131784
dc.identifier.citationNatural Product Research.
dc.identifier.doi10.1080/14786419.2022.2131784
dc.identifier.issn1478-6427
dc.identifier.issn1478-6419
dc.identifier.scopus2-s2.0-85139552257
dc.identifier.urihttp://hdl.handle.net/11449/247724
dc.language.isoeng
dc.relation.ispartofNatural Product Research
dc.sourceScopus
dc.subjecthinokinin
dc.subjectlarvicidal activity
dc.subjectlignans
dc.subjectUDP-N-acetylglucosamine pyrophosphorylase
dc.titleLarvicidal potential of extracts and isolated compounds from Piper cubeba fruits against Aedes aegypti (Diptera: Culicidae) larvaeen
dc.typeArtigo
unesp.author.orcid0000-0002-9442-4757[4]
unesp.author.orcid0000-0003-1981-834X[7]
unesp.departmentFísica e Química - FEISpt

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Ilha Solteira - FEIS - Faculdade de Engenharia