Nanoparticle mucoadhesive system as a new tool for fish immune system modulation

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dc.contributor.authorCharlie-Silva, Ives
dc.contributor.authorde Melo, Nathalie Ferreira Silva
dc.contributor.authorGomes, Juliana M.M.
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorde Melo, Daniela Chemim
dc.contributor.authorde Oliveira Silva, Juliana
dc.contributor.authorde Barros, André Luis Branco
dc.contributor.authorCorrêa, José Dias
dc.contributor.institutionBrasil University (UnBR)
dc.contributor.institutionFaculty of Medicine São Leopoldo Mandic
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:37:42Z
dc.date.available2018-12-11T17:37:42Z
dc.date.issued2018-09-01
dc.description.abstractRecently, chitosan-based nanoparticles with mucoadhesive properties emerged as a strategy for mucosal drug release. This study aimed to characterize the interaction of mucoadhesive system chitosancoated PLGA nanoparticles (NPMA) with fish external mucus. NP suspensions with fluorescent probe were prepared and characterized by size, polydispersity, zeta potential and pH measures. In post-exposure fish were observed an increase in fluorescence imaging over time and it was significantly influenced by NPMA concentration. We also observed the main predominance the fluorescence in the spleen, followed by liver, gill and other tissues. The use of mucoadhesive nanocarriers becomes an alternative for administration of drugs and immunomodulators in immersion systems since the nanosystem can adhere to the mucosal surface of the fish with little residual effect in the water.en
dc.description.affiliationLaboratory of Immunology Brasil University (UnBR), Campus Itaquera
dc.description.affiliationDepartment of Immunology and Biochemistry Faculty of Medicine São Leopoldo Mandic
dc.description.affiliationDepartment of Morphology ICB-UFMG
dc.description.affiliationSão Paulo State University (UNESP) Institute of Science and Technology of Sorocaba
dc.description.affiliationAquiculture Laboratory (Laqua) UFMG
dc.description.affiliationDepartment of Clinical and Toxicological Analyses Faculty of Pharmacy-UFMG
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Science and Technology of Sorocaba
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdCNPq: 301473/2016-1
dc.description.sponsorshipIdFAPEMIG: APQ-02913-17
dc.format.extent651-654
dc.identifierhttp://dx.doi.org/10.1016/j.fsi.2018.05.057
dc.identifier.citationFish and Shellfish Immunology, v. 80, p. 651-654.
dc.identifier.doi10.1016/j.fsi.2018.05.057
dc.identifier.file2-s2.0-85049803448.pdf
dc.identifier.issn1095-9947
dc.identifier.issn1050-4648
dc.identifier.scopus2-s2.0-85049803448
dc.identifier.urihttp://hdl.handle.net/11449/180022
dc.language.isoeng
dc.relation.ispartofFish and Shellfish Immunology
dc.relation.ispartofsjr1,126
dc.relation.ispartofsjr1,126
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectChitosan-coated PLGA nanoparticles
dc.subjectImmunomodulators
dc.subjectMucoadhesive nanoparticles
dc.subjectNanodelivery
dc.titleNanoparticle mucoadhesive system as a new tool for fish immune system modulationen
dc.typeArtigo
unesp.author.orcid0000-0002-7641-6585[7]
unesp.author.orcid0000-0002-8623-8524[8]

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Artigos - Engenharia Ambiental - Sorocaba