Genetic Ancestry of 1127 Brazilian Breast Cancer Patients and Its Correlation With Molecular Subtype and Geographic Region

Página do item simplificado
dc.contributor.authorda Costa Vieira, René Aloisio
dc.contributor.authorSant'Anna, Débora
dc.contributor.authorLaus, Ana Carolina
dc.contributor.authorBacchi, Carlos Eduardo
dc.contributor.authorSilva, René Julias Costa
dc.contributor.authorde Oliveira-Junior, Idam
dc.contributor.authorda Silva, Vinicius Duval
dc.contributor.authorPereira, Rui
dc.contributor.authorReis, Rui Manuel
dc.contributor.institutionBarretos Cancer Hospital
dc.contributor.institutionBotucatu School of Medicine
dc.contributor.institutionBacchi Laboratory
dc.contributor.institutionIPATIMUP
dc.contributor.institutionUniversity of Minho
dc.contributor.institutionICVS/3B's-PT Government Associate Laboratory
dc.date.accessioned2023-07-29T14:01:46Z
dc.date.available2023-07-29T14:01:46Z
dc.date.issued2023-01-01
dc.description.abstractPurpose: Breast cancer molecular subtypes show significant differences in different ethnic groups in the United States, but no study has evaluated genetic ancestry in breast cancer in Brazilian women. Methods: Breast cancer patients from distinct parts of Brazil were evaluated. Molecular subtypes were determined by immunohistochemistry. Genetic ancestry was evaluated using a panel of 46 AIMs (ancestry informative markers), which classified genetic ancestry as European, African, Asian, and Amerindian. PCR products were subjected to capillary electrophoresis and analyzed using GeneMapper 4.0 software. Ancestry was evaluated with Structure v.2.3.3 software. Ancestry was tested for correlations with geographic region and molecular subtype. The chi-square test and ANOVA with Bonferroni adjustment were applied. Results: Genetic ancestry and clinical data were evaluated in 1127 patients. Higher rates of self-reported white ethnicity, European ancestry, and HER-2− luminal tumors were identified in the South region, which may influence age at diagnosis and result in a higher rate of early tumors. Conversely, higher rates of African ancestry in the North and Northeast regions, self-reported nonwhite ethnicity, HER-2+ tumors, and triple-negative tumors were noted. Triple-negative and HER-2+ tumors were associated with higher advanced and metastatic disease rates at diagnosis, with triple-negative tumors being more frequent in young women. Conclusion: Differences in genetic ancestry, self-reported ethnicity, and molecular subtype were found between Brazilian demographic regions. Knowledge of these features may contribute to a better understanding of age at diagnosis and the molecular distribution of breast cancer in Brazil.en
dc.description.affiliationMolecular Oncology Research Center Barretos Cancer Hospital, SP
dc.description.affiliationPostgraduate Program in Oncology Barretos Cancer Hospital, SP
dc.description.affiliationPostgraduate Program in Tocogynecology Botucatu School of Medicine, SP
dc.description.affiliationBacchi Laboratory, SP
dc.description.affiliationDepartment of Pathology Barretos Cancer Hospital, SP
dc.description.affiliationIPATIMUP
dc.description.affiliationLife and Health Sciences Research Institute (ICVS) Medical School University of Minho
dc.description.affiliationICVS/3B's-PT Government Associate Laboratory
dc.identifierhttp://dx.doi.org/10.1016/j.clbc.2023.04.001
dc.identifier.citationClinical Breast Cancer.
dc.identifier.doi10.1016/j.clbc.2023.04.001
dc.identifier.issn1938-0666
dc.identifier.issn1526-8209
dc.identifier.scopus2-s2.0-85159209057
dc.identifier.urihttp://hdl.handle.net/11449/249077
dc.language.isoeng
dc.relation.ispartofClinical Breast Cancer
dc.sourceScopus
dc.subjectBreast neoplasms
dc.subjectContinental population groups
dc.subjectEpidemiology
dc.subjectGenetic identity
dc.subjectPathology
dc.titleGenetic Ancestry of 1127 Brazilian Breast Cancer Patients and Its Correlation With Molecular Subtype and Geographic Regionen
dc.typeArtigo
unesp.author.orcid0000-0003-2014-9016 0000-0003-2014-9016 0000-0003-2014-9016[1]

Arquivos

Coleções

Artigos - Ginecologia e Obstetrícia - FMB