Antiprotozoal activity of the cyclopalladated complexes against leishmania amazonensis and trypanosoma cruzi

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dc.contributor.authorVelásquez, Angela M. A. [UNESP]
dc.contributor.authorDe Souza, Rodrigo A. [UNESP]
dc.contributor.authorPassalacqua, Thaís G. [UNESP]
dc.contributor.authorRibeiro, Aline R.
dc.contributor.authorScontri, Mateus [UNESP]
dc.contributor.authorChin, Chung M. [UNESP]
dc.contributor.authorDe Almeida, Leticia [UNESP]
dc.contributor.authorCistia, Mayara L. Del [UNESP]
dc.contributor.authorRosa, João A. Da [UNESP]
dc.contributor.authorMauro, Antonio E. [UNESP]
dc.contributor.authorGraminha, Marcia A. S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2018-12-11T17:28:24Z
dc.date.available2018-12-11T17:28:24Z
dc.date.issued2016-06-01
dc.description.abstractThe present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba)(μ-Cl)]2 , [Pd(dmba)(NCO)(isn)], [Pd(dmba)(N3)(isn)] and [Pd(dmba)(μ-NCO)]2 , (dmba: N,N'-dimethylbenzylamine and isn: isonicotinamide), against the diseases leishmaniasis (Leishmania amazonensis and Leishmania infantum), Chagas disease (Trypanosoma cruzi) and human African trypanosomiasis (Trypanosoma brucei). [Pd(dmba)(μ-NCO)]2 exhibited good leishmanicidal and trypanocidal activities against L. amazonensis and T. cruzi intracellular amastigote forms, with a 50% inhibitory concentration (IC50 ) value of less than 9 μM and selectivity indexes of 14.47 and 28.42, respectively. Stability essays were conducted in phosphate buffer saline (PBS) pH 7.0 and showed that [Pd(dmba)(μ-NCO)]2 is the most stable molecule. These findings indicate that this compound presented higher selectivity for these parasites than the other tested compounds. The data presented here suggest that this compound should be considered in the development of new and more potent drugs for the treatment of leishmaniasis and Chagas disease.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista UNESP
dc.description.affiliationInstituto de Química Universidade Estadual Paulista UNESP
dc.description.affiliationInstituto de Ciências Biológicas Universidade Estadual de Campinas
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista UNESP
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1032-1039
dc.identifierhttp://dx.doi.org/10.5935/0103-5053.20150360
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 27, n. 6, p. 1032-1039, 2016.
dc.identifier.doi10.5935/0103-5053.20150360
dc.identifier.fileS0103-50532016000601032.pdf
dc.identifier.issn1678-4790
dc.identifier.issn0103-5053
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.scieloS0103-50532016000601032
dc.identifier.scopus2-s2.0-84973308510
dc.identifier.urihttp://hdl.handle.net/11449/178060
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofsjr0,357
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectChagas disease
dc.subjectCyclopalladated
dc.subjectLeishmania amazonensis
dc.subjectLeishmaniasis
dc.subjectTrypanosoma cruzi
dc.subjectTrypanosomiasis
dc.titleAntiprotozoal activity of the cyclopalladated complexes against leishmania amazonensis and trypanosoma cruzien
dc.typeArtigo
unesp.author.lattes3300223970814448[10]
unesp.author.lattes9734333607975413[6]
unesp.author.orcid0000-0003-4141-0455[6]

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