Pulmonary paracoccidioidomycosis in immunized mice

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dc.contributor.authorFaveri, Julio de [UNESP]
dc.contributor.authorRezkallah -Iwasso, M. T. [UNESP]
dc.contributor.authorFranco, M. F.
dc.contributor.institutionSchool of Medicine
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:28Z
dc.date.available2014-05-27T11:17:28Z
dc.date.issued1992-07-01
dc.description.abstractParacoccidioidomycosis was induced in immunized (IM) and non-immunized (NI) mice. The histopathology, the number of fungi in the lungs, the cellular (footpad test - FPT and macrophage inhibition factor assay - MIF) and humoral (immunodiffusion test) immune response were investigated serially postinfection. In the IM mice, at days 1 and 3, there was intense and predominant macrophagic-lymphocytic alveolitis with loose granulomatous reaction; at day 30, inflammation was mild. In the NI group, up to day 3, the lesions were focal; later there was formation of extensive epithelioid granuloma. The number of fungi in IM mice were always smaller than those of NI group. Immunization alone induced positive FPT and MIF indices with low titer of antibody. After infection, there was a significant decrease of the FPT indices in the IM group, which we interpreted as desensitization due to trapping of sensitized lymphocytes in the lungs. In conclusion, (1) The lesional pattern of pulmonary paracoccidioidomycosis in IM mice was similar to that of a hypersensitivity pneumonitis. This reaction was probably effective in reducing the extension of the infection and decrease the number of fungi. (2) In this model, pulmonary resistance against P. brasiliensis seems to be related to local and systemic delayed-type hypersensitivity reaction. © 1992 Kluwer Academic Publishers.en
dc.description.affiliationDepartment of Pathology School of Medicine, Botucatu, 18610 SP
dc.description.affiliationBiosciences Institute UNESP, Botucatu, 18610 SP
dc.description.affiliationUnespBiosciences Institute UNESP, Botucatu, 18610 SP
dc.format.extent1-9
dc.identifierhttp://link.springer.com/article/10.1007%2FBF00492223
dc.identifier.citationMycopathologia, v. 119, n. 1, p. 1-9, 1992.
dc.identifier.issn0301-486X
dc.identifier.issn1573-0832
dc.identifier.scopus2-s2.0-0026885332
dc.identifier.urihttp://hdl.handle.net/11449/64246
dc.identifier.wosWOS:A1992JK29900001
dc.language.isoeng
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.relation.ispartofsjr0,597
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectimmunization
dc.subjectParacoccidioidomycosis
dc.subjectfungus antigen
dc.subjectanimal
dc.subjectbacterial count
dc.subjectcellular immunity
dc.subjectimmunodiffusion
dc.subjectimmunology
dc.subjectleukocyte migration inhibition test
dc.subjectlung mycosis
dc.subjectmale
dc.subjectmicrobiology
dc.subjectmouse
dc.subjectParacoccidioides
dc.subjectpathology
dc.subjectSouth American blastomycosis
dc.subjectAnimal
dc.subjectAntigens, Fungal
dc.subjectCell Migration Inhibition
dc.subjectColony Count, Microbial
dc.subjectImmunity, Cellular
dc.subjectImmunodiffusion
dc.subjectLung Diseases, Fungal
dc.subjectMale
dc.subjectMice
dc.subjectSupport, Non-U.S. Gov't
dc.titlePulmonary paracoccidioidomycosis in immunized miceen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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