Excess androgen during perinatal life alters steroid receptor expression, apoptosis, and cell proliferation in the uteri of the offspring

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dc.contributor.authorGuerra, Marina T.
dc.contributor.authorSanabria, Marciana [UNESP]
dc.contributor.authorGrossman, Gail
dc.contributor.authorPetrusz, Peter
dc.contributor.authorKempinas, Wilma de Grava [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of North Carolina
dc.date.accessioned2014-05-27T11:30:32Z
dc.date.available2014-05-27T11:30:32Z
dc.date.issued2013-09-01
dc.description.abstractExposure to environmental chemicals may contribute to reproductive disorders, especially when it occurs in critical periods of development. The female reproductive system can be a target for androgens derived from environmental contaminants or pathological conditions. The purpose of this study was to assess the long-term effects of androgens on uterine tissue after maternal exposure limited to the time of gestation and lactation. Pregnant Wistar rats were treated with testosterone propionate (TP) at 0.05. mg/kg, 0.1. mg/kg, 0.2. mg/kg or corn oil (vehicle), s.c., from gestational day 12 until the end of lactation. The results show changes in the pattern of expression of receptors for estrogen, progesterone, and androgen at all doses tested, and decreases in both apoptosis and cell proliferation indices at 0.1 and 0.2. mg/kg. We conclude that early TP exposure, under these experimental conditions, causes changes in cellular and molecular parameters that are essential for normal uterine function in the adult. © 2013 Elsevier Inc.en
dc.description.affiliationGraduate Program in Cell and Structural Biology Institute of Biology State University of Campinas - UNICAMP, Campinas, SP
dc.description.affiliationInstitute of Biosciences Universidade Estadual Paulista (UNESP) Department of Morphology, Botucatu, SP
dc.description.affiliationDepartment of Cell and Developmental Biology Laboratories for Reproductive Biology University of North Carolina, Chapel Hill, NC
dc.description.affiliationUnespInstitute of Biosciences Universidade Estadual Paulista (UNESP) Department of Morphology, Botucatu, SP
dc.format.extent1-7
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2013.05.001
dc.identifier.citationReproductive Toxicology, v. 40, p. 1-7.
dc.identifier.doi10.1016/j.reprotox.2013.05.001
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.lattes6326450271169741
dc.identifier.scopus2-s2.0-84879518314
dc.identifier.urihttp://hdl.handle.net/11449/76419
dc.identifier.wosWOS:000322849300001
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectFemale reproduction
dc.subjectHyper-androgenic condition
dc.subjectImmunohistochemistry
dc.subjectSteroid receptors
dc.subjectUterus
dc.subjectandrogen
dc.subjectandrogen receptor
dc.subjectcycline
dc.subjectestrogen receptor alpha
dc.subjectprogesterone receptor
dc.subjectsteroid receptor
dc.subjecttestosterone propionate
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectcell proliferation
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectimmunohistochemistry
dc.subjectlactation
dc.subjectnonhuman
dc.subjectperinatal drug exposure
dc.subjectrat
dc.subjectuterus
dc.subjectuterus weight
dc.titleExcess androgen during perinatal life alters steroid receptor expression, apoptosis, and cell proliferation in the uteri of the offspringen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes6326450271169741
unesp.author.orcid0000-0002-2112-5123[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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