Effect of propolis, some isolated compounds and its source plant on antibody production

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dc.contributor.authorSforcin, J. M.
dc.contributor.authorOrsi, R. O.
dc.contributor.authorBankova, V
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBulgarian Acad Sci
dc.date.accessioned2014-05-20T13:50:35Z
dc.date.available2014-05-20T13:50:35Z
dc.date.issued2005-04-26
dc.description.abstractPropolis is a beehive product with a very complex chemical composition, widely used in folk medicine because of its several therapeutic activities. Its biological properties and chemical composition may vary according to the geographic location and to the different plant sources. The possible mechanism of action of propolis as well as of its active compounds has been the subject of researchers in recent years. In this work, first we reported the results of our study on the seasonal effect of the immunomodulatory action of propolis on antibody production in bovine serum albumin (BSA)-immunized rats. Then, we compared the effect of Brazilian and Bulgarian propolis, some isolated compounds and Baccharis extract on anti-BSA antibody levels. Based on the results, we conclude that propolis stimulates antibody production, independently of the season and geographic origin. Caffeic acid, quercetin and Baccharis extract had no effect on antibody production, although the importance of isolated compounds is well reported in other biological assays. Propolis action is a consequence of plant-derived products with synergic effects. while isolated compounds or extracts from its plant sources had no effect in this assay. (c) 2005 Elsevier B.V.. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Biosci Inst, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationBulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, BU-1113 Sofia, Bulgaria
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Biosci Inst, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent301-305
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2005.01.042
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 98, n. 3, p. 301-305, 2005.
dc.identifier.doi10.1016/j.jep.2005.01.042
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/11449/18061
dc.identifier.wosWOS:000228688300011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpropolispt
dc.subjectantibodypt
dc.subjectcaffeic acidpt
dc.subjectquercetinpt
dc.subjectBaccharispt
dc.titleEffect of propolis, some isolated compounds and its source plant on antibody productionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0001-8099-8277[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB