EFEITOS DO SULFATE DE MAGNESIO NA HEMODINAMICA E FUNCAO RENAL DE CAES ANESTESIADOS CORN PENTOBARBITAL SODICO

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dc.contributor.authorGanem, Eliana Marisa [UNESP]
dc.contributor.authorCastiglia, Yara Marcondes Machado [UNESP]
dc.contributor.authorVianna, Pedro Thadeu Galvão [UNESP]
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:03Z
dc.date.available2014-05-27T11:18:03Z
dc.date.issued1996-01-01
dc.description.abstractBackground and objectives - The use of magnesium sulphate for the prevention of seizures in pre-eclampsia may induce hypermagnesemia. Clinical and experimental studies are not in agreement about the effects of magnesium on the renal hemodynamics and function. We therefore studied the effects of hypermagnesemia on the renal hemodynamics and function of dogs anesthetized with pentobarbitone. Methods - Sixteen mongrel dogs were anesthetized with pentobarbitone 30 mg.kg-1 and submitted to extracellular ) and mechanical ventilation with room air. The dogs were volume expansion with Ringer's solution (0.4 ml.kg.min allocated into two groups of 8 animals, for the study of renal hemodynamics and function following the administration of 5 mg.kg-1 of pentobarbitone (Group 1 - control or of pentobarbitone associated with magnesium sulphate in the dose (Group 2). The parameters studied were: PAH of 140 mg.kg, administered in 15 minutes, followed by 80 mg.kg-1.h-1 clearance, creatinine clearance, osmolar clearance, free water clearance, renal blood flow, renal vascular resistance, filtration fraction, urinary volume, plasmatic and urinary osmolarity, urinary and fractionary excretion of sodium and potassium, measured at five moments: 15 (M1), 30 (M2), 60 (M3) and 75 (M4) minutes after the first supplementary dose of pentobarbitone and 15 minutes (M5) after the second supplementary dose in Group 1. In Group 2, the moments M3, M4, M5 were 15, 30 and 60 minutes after the priming dose of magnesium sulphate and during the maintenance dose. Results - In Group I no significant changes were observed in renal hemodynamic parameters and creatinine clearance. The extracellular volume expansion increased urinary volume and decreased urinary osmolarity as a consequence of sodium, potassium and free water clearance. The fractionary excretion of sodium was maintained. The plasmatic osmolarity increased. In Group 2, renal hemodynamic parameters and creatinine clearance were also maintained. There was an increase in renal sodium clearance, as detected by the increase in the fractionary excretion of sodium. Conclusions - Magnesium sulphate did not produce significant changes in renal hemodynamics and facilitated the renal excretion of sodium in dogs anesthetized with pentobarbitone.en
dc.description.affiliationDepartamento de Anestesiologia Faculdade de Medicina UNESP, Caixa Postal 530, 18618-970-Botucatu-SP
dc.description.affiliationUnespDepartamento de Anestesiologia Faculdade de Medicina UNESP, Caixa Postal 530, 18618-970-Botucatu-SP
dc.format.extent122-129
dc.identifierhttp://www.sba.com.br/arquivos/revista/rba/mar96122.pdf
dc.identifier.citationRevista Brasileira de Anestesiologia, v. 46, n. 2, p. 122-129, 1996.
dc.identifier.file2-s2.0-0029967841.pdf
dc.identifier.issn0034-7094
dc.identifier.lattes8226942130768820
dc.identifier.lattes8223546475724058
dc.identifier.scopus2-s2.0-0029967841
dc.identifier.urihttp://hdl.handle.net/11449/64725
dc.language.isospa
dc.relation.ispartofRevista Brasileira de Anestesiologia
dc.relation.ispartofjcr0.850
dc.relation.ispartofsjr0,320
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnesthetic tecniques: venous
dc.subjectAnimal: dog
dc.subjectDrugs: magnesium sulphate, pentobarbitone
dc.subjectExperimental anesthesia
dc.subjectRenal system: function
dc.subject4 aminohippuric acid
dc.subjectanticonvulsive agent
dc.subjectcreatinine
dc.subjectmagnesium sulfate
dc.subjectpentobarbital
dc.subject4 aminohippuric acid clearance
dc.subjectanimal experiment
dc.subjectartificial ventilation
dc.subjectcontrolled study
dc.subjectcreatinine clearance
dc.subjectdog
dc.subjectfree water clearance
dc.subjectglomerulus filtration
dc.subjecthypermagnesemia
dc.subjectkidney blood flow
dc.subjectkidney function
dc.subjectkidney vascular resistance
dc.subjectnonhuman
dc.subjectosmotic diuresis
dc.subjectplasma osmolarity
dc.subjectpotassium urine level
dc.subjectpreeclampsia
dc.subjectseizure
dc.subjectsodium urine level
dc.subjecturine osmolality
dc.subjecturine volume
dc.titleEFEITOS DO SULFATE DE MAGNESIO NA HEMODINAMICA E FUNCAO RENAL DE CAES ANESTESIADOS CORN PENTOBARBITAL SODICOes
dc.title.alternativeEffects of magnesium sulphate on the renal hemodynamics and function of dogs anesthetized with pentobarbitoneen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rba/paboutj.htm
unesp.author.lattes8226942130768820
unesp.author.lattes8223546475724058
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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