Determinação de fármacos diuréticos em associação por cromatografia em camada delgada e espectrofotometria

dc.contributor.authorValladão, Dênia Mendes de Sousa
dc.contributor.authorIonashiro, Massao [UNESP]
dc.contributor.authorNetto, José Zuanon
dc.contributor.institutionUniversidade do Estado do Mato Grosso (UEMT)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:49Z
dc.date.available2014-05-27T11:22:49Z
dc.date.issued2008-03-11
dc.description.abstractA rapid, sensitive and reliable thin-layer chromatography/spectrophotometry screening procedure was developed for quantitative determination of diuretics associated in pharmaceutical dosage forms. The chromatographic method employed microcrystalline cellulose and butanol : acetic acid : water (4:1:1) or amilic alcohol : ammonium hydroxide 25% (9:1) as mobile phases and detection by U.V. light. The drugs were extracted using a simple procedure and were quantified by U.V. spectrophotometry. Results varied from 97.5 to 102.5% and are similar to those obtained by conventional methods. This method of quantification of diuretics is promising for quality control of drugs.en
dc.description.affiliationDepartamento de Engenharia Campus de Sinop Universidade do Estado do Mato Grosso, 78850-000 Sinop - MT
dc.description.affiliationDepartamento de Química Analítica Instituto de Química de Araraquara, CP 355, 14801-970 Araraquara - SP
dc.format.extent44-46
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422008000100009
dc.identifier.citationQuimica Nova, v. 31, n. 1, p. 44-46, 2008.
dc.identifier.doi10.1590/S0100-40422008000100009
dc.identifier.file2-s2.0-40349114520.pdf
dc.identifier.issn0100-4042
dc.identifier.issn1678-7064
dc.identifier.lattes8460531302083773
dc.identifier.scieloS0100-40422008000100009
dc.identifier.scopus2-s2.0-40349114520
dc.identifier.urihttp://hdl.handle.net/11449/70347
dc.language.isopor
dc.relation.ispartofQuímica Nova
dc.relation.ispartofjcr0.646
dc.relation.ispartofsjr0,255
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDiuretics
dc.subjectQuality control
dc.subjectThin layer chromatography
dc.titleDeterminação de fármacos diuréticos em associação por cromatografia em camada delgada e espectrofotometriapt
dc.title.alternativeDetermination of diuretic drugs by thin layer chromatography and spectrophotometryen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/qn/paboutj.htm#03
unesp.author.lattes8460531302083773
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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