Current outlook of ethics in research with human subjects

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dc.contributor.authorTakahashi, Marystella Tomoe
dc.contributor.authorRamos, Henrique Faria
dc.contributor.authorPinheiro-Neto, Carlos Diógenes
dc.contributor.authorMiziara, Ivan Dieb [UNESP]
dc.contributor.authorde Oliveira, Reynaldo Ayer
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:44:25Z
dc.date.available2022-04-29T08:44:25Z
dc.date.issued2011-01-01
dc.description.abstractIn the last decades, medical care has been increasingly permeated by the concept of evidence-based-medicine, in which clinical research plays a crucial role in establishing diagnostic and treatment. Following the improvements in clinical research, we have a growing concern and understanding that some ethical issues must be respected when the subjects are human beings. Research with human subjects relies on the principles of autonomy, beneficence, no maleficence and justice. Ordinance 196/96 from the national Health Board adds to the Brazilian legislation such renowned bioethical principles. Aim: discuss the main ethical aspects involved in research with human subjects. Materials and Methods: Critical analysis of Ordinance 196/96 and related literature. Conclusion: Ordinance 196/96 rules research with human subjects; nevertheless, it requires more in-depth discussions regarding the informed consent, use of placebo, research with vulnerable populations and research in developing countries.en
dc.description.affiliationCollaboratng Physician from the Group of Voice - ENT Division University Hospital Medical School of the University of São Paulo, R. Otávio Nébias 98 ap. 121 Vila Mariana, São Paulo SP 04002-010
dc.description.affiliationDepartment of Otorhinolaryngology University Hospital Medical School of the University of São Paulo
dc.description.affiliationMedical School of the University of São Paulo Department of Otorhinolaryngology University Hospital Medical School of the University of São Paulo
dc.description.affiliationState University of São Paulo Júlio de Mesquita Filho UNESP
dc.description.affiliationDepartment of Forensic Medicine Medical Ethics Social Medicine and Occupatonal Medicine Medical School of the University of São Paulo
dc.description.affiliationUnespState University of São Paulo Júlio de Mesquita Filho UNESP
dc.format.extent263-266
dc.identifierhttp://dx.doi.org/10.1590/S1808-86942011000200018
dc.identifier.citationBrazilian Journal of Otorhinolaryngology, v. 77, n. 2, p. 263-266, 2011.
dc.identifier.doi10.1590/S1808-86942011000200018
dc.identifier.issn1808-8686
dc.identifier.issn1808-8694
dc.identifier.scopus2-s2.0-79960376528
dc.identifier.urihttp://hdl.handle.net/11449/231265
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.sourceScopus
dc.subjectBioethics
dc.subjectCodes of ethics
dc.subjectEthics
dc.subjectEthics committees
dc.subjectPrinciple-bases ethics
dc.subjectResearch
dc.titleCurrent outlook of ethics in research with human subjectsen
dc.typeResenha

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