Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors

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dc.contributor.authorAmerico, Márcia Gimenes [UNESP]
dc.contributor.authorMarques, Yonara Maria Freire Soares [UNESP]
dc.contributor.authorEl Abras Ankha, Milagros Del Valle [UNESP]
dc.contributor.authordo Prado, Renata Falchete [UNESP]
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:03:12Z
dc.date.available2018-12-11T17:03:12Z
dc.date.issued2017-03-01
dc.description.abstractLymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland tumors present different prognoses and have the ability to develop metastases; however, this information regarding the lymphatic spread is scarce. This paper quantifies the lymphatic microvessel density (LMD) in benign and malignant salivary gland tumors and analyzes the relationship between LMD and tumor expression of vascular endothelial growth factors C (VEGF-C) and the proliferative index. The results show that there is no correlation between LMD, VEGF-C and the proliferative index in the majority of salivary gland tumors analyzed, apart from polymorphous low-grade carcinoma which exhibits statistical correlation between LMD and the proliferative index (p < 0.05). This correlation probably does not indicate a poor prognosis for this PLGA, since this is a low metastasizing carcinoma of the salivary glands. Different from other solid tumors, such as breast or prostatic carcinomas, there is no correlation between VEGF-C and LMD in salivary gland tumors, and so these traits are not able to estimate the metastatic risk or the prognosis of these tumors.en
dc.description.affiliationDepartment of Bioscience and Oral Diagnosis Dental School-Institute of Science and Technology (ICT) Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos
dc.description.affiliationUnespDepartment of Bioscience and Oral Diagnosis Dental School-Institute of Science and Technology (ICT) Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos
dc.format.extent17-24
dc.identifierhttp://dx.doi.org/10.1007/s00795-016-0142-7
dc.identifier.citationMedical Molecular Morphology, v. 50, n. 1, p. 17-24, 2017.
dc.identifier.doi10.1007/s00795-016-0142-7
dc.identifier.file2-s2.0-84971673768.pdf
dc.identifier.issn1860-1499
dc.identifier.issn1860-1480
dc.identifier.scopus2-s2.0-84971673768
dc.identifier.urihttp://hdl.handle.net/11449/173032
dc.language.isoeng
dc.relation.ispartofMedical Molecular Morphology
dc.relation.ispartofsjr0,506
dc.relation.ispartofsjr0,506
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectLymphatic microvessel density
dc.subjectPrognoses
dc.subjectProliferative index
dc.subjectSalivary gland tumors
dc.subjectVEGF-C
dc.titleCorrelation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumorsen
dc.typeArtigo

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Artigos - Biociências e Diagnóstico Bucal - ICT