Dysplastic melanocytic nevus: Are molecular findings the key to the diagnosis?

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dc.contributor.authorXavier-Junior, José Cândido Caldeira [UNESP]
dc.contributor.authorOcanha-Xavier, Juliana Polizel [UNESP]
dc.contributor.institutionPathology Institute of Araçatuba
dc.contributor.institutionCentro Universitário Católico Salesiano Auxilium (Unisalesiano)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-01T21:16:36Z
dc.date.available2023-03-01T21:16:36Z
dc.date.issued2022-10-01
dc.description.abstractThe primary differential diagnosis of melanoma is dysplastic nevus. Until now, the final diagnosis is based on histological findings. With modern techniques, pathologists receive very early melanocytic lesions, which do not fit all malignant criteria. In those cases, even the concurrence between specialists and intraobserver agreement is not good. A molecular test could be developed to improve the accuracy of melanocytic lesions diagnosis and help in challenging lesions. The objective of this study is to provide a literary review looking for molecular markers that characterize dysplastic nevi and could help surgical pathologists differentiate them from melanoma. Articles from PubMed presenting case series of dysplastic nevi and melanoma genomic analyses were considered. The search was conducted in PubMed looking for papers written in English, published in the ten years preceding April 2020. This review confirmed the absence of a pathognomonic molecular marker of dysplastic nevi. This is a heterogeneous group of lesions with an uncertain risk to become a melanoma. The molecular heterogeneity of dysplastic nevi, the variation of histological diagnostic criteria among services, and the diverse molecular techniques applied are challenging features that might hamper definitive diagnoses. However, currently, there appears to be limited value for molecular testing in the diagnosis of dysplastic nevi.en
dc.description.affiliationPathology Institute of Araçatuba, SP
dc.description.affiliationSchool of Medicine Centro Universitário Católico Salesiano Auxilium (Unisalesiano), SP
dc.description.affiliationSchool of Medicine Paulista State University, SP
dc.description.affiliationUnespSchool of Medicine Paulista State University, SP
dc.identifierhttp://dx.doi.org/10.1016/j.anndiagpath.2022.152006
dc.identifier.citationAnnals of Diagnostic Pathology, v. 60.
dc.identifier.doi10.1016/j.anndiagpath.2022.152006
dc.identifier.issn1532-8198
dc.identifier.issn1092-9134
dc.identifier.scopus2-s2.0-85134494655
dc.identifier.urihttp://hdl.handle.net/11449/241683
dc.language.isoeng
dc.relation.ispartofAnnals of Diagnostic Pathology
dc.sourceScopus
dc.subjectGenetic database
dc.subjectMelanoma
dc.subjectMolecular biology
dc.subjectNevus
dc.subjectPathology
dc.titleDysplastic melanocytic nevus: Are molecular findings the key to the diagnosis?en
dc.typeResenha
unesp.author.orcid0000-0003-0503-419X 0000-0003-0503-419X 0000-0003-0503-419X[1]
unesp.author.orcid0000-0002-1200-3730[2]

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