Characterization of the vaginal microbiome in women of reproductive age from 5 Regions in Brazil

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dc.contributor.authorMarconi, Camila [UNESP]
dc.contributor.authorEl-Zein, Mariam
dc.contributor.authorRavel, Jacques
dc.contributor.authorMa, Bing
dc.contributor.authorLima, Moises D.
dc.contributor.authorCarvalho, Newton Sergio
dc.contributor.authorAlves, Rosane R F.
dc.contributor.authorParada, Cristina M G L. [UNESP]
dc.contributor.authorLeite, Sandra H M.
dc.contributor.authorGiraldo, Paulo C.
dc.contributor.authorGonçalves, Ana K.
dc.contributor.authorFranco, Eduardo L.
dc.contributor.authorSilva, Marcia G. [UNESP]
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMcGill University
dc.contributor.institutionUniversity of Maryland School of Medicine
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionState University of Pará (UEPA)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2020-12-12T02:16:41Z
dc.date.available2020-12-12T02:16:41Z
dc.date.issued2020-08-01
dc.description.abstractBackground Composition of the vaginal microbiome is strongly related to a woman's reproductive health and risk of sexually transmitted infections. Ethnoracial, behavioral, and environmental factors can influence microbiome. The Brazilian population is unique in terms of miscegenation of ethnic groups and behavioral characteristics across different regions. We aimed to characterize the vaginal microbiome of women from 5 geographical regions of Brazil. Methods We sequenced V3-V4 regions of 16S rRNA gene in vaginal samples of 609 reproductive-aged women. We performed logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between sociodemographic and behavioral factors with Lactobacillus-depleted microbiome (community state type [CST] IV). Results Vaginal samples were grouped into 5 CST: CST I (L. crispatus predominant, 30.5%), CST II (L. gasseri predominant, 4.4%), CST III (Lactobacillus iners predominant, 36.5%), CST IV (Lactobacillus-depleted, 27.4%), and CST V (L. jensenii predominant, 1.2%). Several factors were independently associated with CST IV, such as smoking (OR, 1.80; 95% CI, 1.02-3.18), number of partners (OR, 2.11; 95% CI, 1.20-3.70), and vaginal douching (OR, 2.24; 95% CI, 1.34-3.74). A protective effect was observed for milk/dairy intake (OR, 0.47; 95% CI, 0.27-0.82) and sitz bathing (OR, 0.43; 95% CI, 0.19-0.98). Conclusions Nearly two thirds of Brazilian women may be at an increased risk for adverse outcomes associated with a vaginal microbiota characterized by the depletion of Lactobacillus or dominance by L. iners, whose protective role has been widely questioned. Several factors related to sexual behavior and intimate hygiene were associated with CST IV.en
dc.description.affiliationDepartment of Basic Pathology Federal University of Paraná (UFPR)
dc.description.affiliationDepartment of Pathology Botucatu Medical School Sao Paulo State University (UNESP)
dc.description.affiliationDivision of Cancer Epidemiology McGill University
dc.description.affiliationInstitute of Genomic Science University of Maryland School of Medicine
dc.description.affiliationDepartment of Gynecology and Obstetrics Federal University of Paraíba (UFPB)
dc.description.affiliationDepartment of Gynecology and Obstetrics Federal University of Paraná (UFPR)
dc.description.affiliationDepartment of Gynecology and Obstetrics Federal University of Goiás (UFG)
dc.description.affiliationDepartment of Nursing Botucatu Medical School Sao Paulo State University (UNESP)
dc.description.affiliationDepartment of Gynecology and Obstetrics State University of Pará (UEPA)
dc.description.affiliationDepartment of Gynecology and Obstetrics Faculty of Medicine State University of Campinas (UNICAMP)
dc.description.affiliationDepartment of Gynecology and Obstetrics Faculty of Medicine Federal University of Rio Grande Do Norte (UFPR)
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School Sao Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Nursing Botucatu Medical School Sao Paulo State University (UNESP)
dc.format.extent562-569
dc.identifierhttp://dx.doi.org/10.1097/OLQ.0000000000001204
dc.identifier.citationSexually Transmitted Diseases, v. 47, n. 8, p. 562-569, 2020.
dc.identifier.doi10.1097/OLQ.0000000000001204
dc.identifier.issn1537-4521
dc.identifier.issn0148-5717
dc.identifier.scopus2-s2.0-85088485758
dc.identifier.urihttp://hdl.handle.net/11449/200809
dc.language.isoeng
dc.relation.ispartofSexually Transmitted Diseases
dc.sourceScopus
dc.titleCharacterization of the vaginal microbiome in women of reproductive age from 5 Regions in Brazilen
dc.typeArtigo

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