An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles

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dc.contributor.authorFlórez, Laura V.
dc.contributor.authorScherlach, Kirstin
dc.contributor.authorMiller, Ian J.
dc.contributor.authorRodrigues, Andre [UNESP]
dc.contributor.authorKwan, Jason C.
dc.contributor.authorHertweck, Christian
dc.contributor.authorKaltenpoth, Martin
dc.contributor.institutionJohannes Gutenberg University
dc.contributor.institutionLeibniz Institute for Natural Products Research and Infection Biology
dc.contributor.institutionUniversity of Wisconsin
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFriedrich Schiller University
dc.date.accessioned2018-12-11T17:21:13Z
dc.date.available2018-12-11T17:21:13Z
dc.date.issued2018-12-01
dc.description.abstractMicrobial symbionts are often a source of chemical novelty and can contribute to host defense against antagonists. However, the ecological relevance of chemical mediators remains unclear for most systems. Lagria beetles live in symbiosis with multiple strains of Burkholderia bacteria that protect their offspring against pathogens. Here, we describe the antifungal polyketide lagriamide, and provide evidence supporting that it is produced by an uncultured symbiont, Burkholderia gladioli Lv-StB, which is dominant in field-collected Lagria villosa. Interestingly, lagriamide is structurally similar to bistramides, defensive compounds found in marine tunicates. We identify a gene cluster that is probably involved in lagriamide biosynthesis, provide evidence for horizontal acquisition of these genes, and show that the naturally occurring symbiont strains on the egg are protective in the soil environment. Our findings highlight the potential of microbial symbionts and horizontal gene transfer as influential sources of ecological innovation.en
dc.description.affiliationDepartment for Evolutionary Ecology Institute of Organismic and Molecular Evolution Johannes Gutenberg University, Johann-Joachim-Becher-Weg 13
dc.description.affiliationDepartment of Biomolecular Chemistry Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstr. 11a
dc.description.affiliationPharmaceutical Sciences Division School of Pharmacy University of Wisconsin, 777 Highland Ave
dc.description.affiliationDepartment of Biochemistry and Microbiology UNESP-São Paulo State University, Av. 24A, n. 1515-Bela Vista
dc.description.affiliationNatural Product Chemistry Friedrich Schiller University
dc.description.affiliationUnespDepartment of Biochemistry and Microbiology UNESP-São Paulo State University, Av. 24A, n. 1515-Bela Vista
dc.identifierhttp://dx.doi.org/10.1038/s41467-018-04955-6
dc.identifier.citationNature Communications, v. 9, n. 1, 2018.
dc.identifier.doi10.1038/s41467-018-04955-6
dc.identifier.file2-s2.0-85049238246.pdf
dc.identifier.issn2041-1723
dc.identifier.scopus2-s2.0-85049238246
dc.identifier.urihttp://hdl.handle.net/11449/176528
dc.language.isoeng
dc.relation.ispartofNature Communications
dc.relation.ispartofsjr6,582
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleAn antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetlesen
dc.typeArtigo
unesp.author.lattes8538509657578022[4]
unesp.author.orcid0000-0002-4164-9362[4]
unesp.author.orcid0000-0001-9933-1536[5]

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Artigos - Bioquímica e Microbiologia - IBRC