Bactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosis

Página do item simplificado
dc.contributor.authorCampos, Debora L. [UNESP]
dc.contributor.authorMachado, Ignacio
dc.contributor.authorRibeiro, Camila M. [UNESP]
dc.contributor.authorGambino, Dinorah
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidad de la República
dc.date.accessioned2020-12-12T01:44:35Z
dc.date.available2020-12-12T01:44:35Z
dc.date.issued2020-02-01
dc.description.abstractThe objective of this study was to determine the activity of pyridine-2-thiol 1-oxide sodium salt (Na mpo) and its complex with iron [Fe(mpo)3] against Mycobacterium tuberculosis. The compounds were tested against a standard strain of M. tuberculosis H37Rv (ATCC 27294), with minimal inhibitory concentrations (MIC90) of 7.20 and 1.07 μM to Na mpo and [Fe(mpo)3], respectively, and against three clinical isolates with different genotypic profiles, with MIC values ranging from 0.74 to 6.52 and 0.30 to 2.25 μM to Na mpo and [Fe(mpo)3], respectively. [Fe(mpo)3] was more effective against susceptible strains but both compounds were effective in inhibiting MDR and XDR-TB clinical strains. The profile activity was determined through the methodology of a time-kill curve against standard and clinical strains of M. tuberculosis. Time-kill studies indicated that Na mpo had an early bactericidal activity against H37Rv and clinical isolates, with sterilizing effects observed in 5 and 7 days, respectively, at its MIC90. The anti MDR and XDR-M. tuberculosis activity and bactericidal effect of Na mpo and [Fe(mpo)3] demonstrate their potential as new compounds for the treatment of tuberculosis.en
dc.description.affiliationDepartment of Biological Sciences Faculty of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationÁrea Química Analítica Facultad de Química Universidad de la República
dc.description.affiliationÁrea Química Inorgánica Facultad de Química Universidad de la República
dc.description.affiliationUnespDepartment of Biological Sciences Faculty of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.format.extent120-124
dc.identifierhttp://dx.doi.org/10.1038/s41429-019-0243-3
dc.identifier.citationJournal of Antibiotics, v. 73, n. 2, p. 120-124, 2020.
dc.identifier.doi10.1038/s41429-019-0243-3
dc.identifier.issn1881-1469
dc.identifier.issn0021-8820
dc.identifier.scopus2-s2.0-85074574429
dc.identifier.urihttp://hdl.handle.net/11449/199613
dc.language.isoeng
dc.relation.ispartofJournal of Antibiotics
dc.sourceScopus
dc.titleBactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosisen
dc.typeArtigo
unesp.author.orcid0000-0001-8678-7374[4]
unesp.author.orcid0000-0002-6969-3963[5]

Arquivos

Coleções

Artigos - Ciências Biológicas - FCFAR