Short-term intradialytic NMES targeting muscles of the legs improves the phase angle: A pilot randomized clinical trial

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dc.contributor.authorMarini, Ana Clara B.
dc.contributor.authorMotobu, Reika D.
dc.contributor.authorFreitas, Ana Tvs
dc.contributor.authorMota, Joao F.
dc.contributor.authorMonteiro, Paula A. [UNESP]
dc.contributor.authorPichard, Claude
dc.contributor.authorLaviano, Alessandro
dc.contributor.authorWall, Benjamin T.
dc.contributor.authorPimentel, Gustavo D.
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionGeneva Univ Hosp
dc.contributor.institutionUniv Roma La Sapienza
dc.contributor.institutionUniv Exeter
dc.date.accessioned2021-06-25T15:05:58Z
dc.date.available2021-06-25T15:05:58Z
dc.date.issued2021-06-01
dc.description.abstractPurpose: Neuromuscular electrical stimulation (NMES) elicits muscle contraction and has been shown to attenuate muscle atrophy when physical activity is not possible. Thus, we hypothesized that intradialytic NMES would attenuate the loss leg lean mass and improve the phase angle in patients undergoing hemodialysis (HD). Methods: A randomized controlled trial was performed with twenty-one adult HD patients (n = 8 F, n = 13 M; 45.8 +/- 10.6 y) randomly assigned to usual care (control group, n = 11; 4F/7M) or to the NMES group (n = 10; 4F/6M). NMES was applied bilaterally at the origin and insertion points of the quadriceps or gastrocnemius muscles for 40 min during each HD session (3x/wk for one month). Pre-and post-intervention, we measured leg lean mass using dual-energy x-ray absorptiometry and phase angle using bioelectrical impedance analysis. Results: NMES did not change leg lean mass compared to the control group. Phase angle increased in the NMES compared to the control group (Delta: +0.71 +/- 0.27 degrees vs. -0.46 +/- 0.23 degrees, p = 0.004) with interaction time x treatment (ANOVA p = 0.004). Conclusion: Short-term intradialytic NMES targeting muscles of the legs improved the phase angle but did not change leg lean mass. Brazilian registry of clinical trials under the code: RBR-98wzgn. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Goias, Fac Nutr, Clin & Sports Nutr Res Lab Labince, Goiania, Go, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, Brazil
dc.description.affiliationGeneva Univ Hosp, Clin Nutr, Geneva, Switzerland
dc.description.affiliationUniv Roma La Sapienza, Dept Translat & Precis Med, Rome, Italy
dc.description.affiliationUniv Exeter, Coll Life & Environm Sci, Dept Sport & Hlth Sci, Exeter, Devon, England
dc.description.affiliationUnespSao Paulo State Univ, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 312252/2019-6
dc.format.extent111-116
dc.identifierhttp://dx.doi.org/10.1016/j.clnesp.2021.03.026
dc.identifier.citationClinical Nutrition Espen. Amsterdam: Elsevier, v. 43, p. 111-116, 2021.
dc.identifier.doi10.1016/j.clnesp.2021.03.026
dc.identifier.issn2405-4577
dc.identifier.urihttp://hdl.handle.net/11449/210357
dc.identifier.wosWOS:000653468300012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofClinical Nutrition Espen
dc.sourceWeb of Science
dc.subjectHemodialysis
dc.subjectPhase angle
dc.subjectNMES
dc.subjectLean body mass
dc.titleShort-term intradialytic NMES targeting muscles of the legs improves the phase angle: A pilot randomized clinical trialen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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