Renal artery clipping attenuates the progression of adriamycin nephropathy

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dc.contributor.authorBalbi, André Luis [UNESP]
dc.contributor.authorFranco, RJS
dc.contributor.authorBarretti, Pasqual [UNESP]
dc.contributor.authorGavras, I
dc.contributor.authorGavras, H.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBoston University
dc.date.accessioned2014-05-20T15:29:41Z
dc.date.available2014-05-20T15:29:41Z
dc.date.issued1998-09-01
dc.description.abstractThis study was designed to analyze the impact of diminished renal perfusion pressure due to renal clipping on the rat model of adriamycin nephropathy. Male Wistar rats, divided into four groups (n = 9 per group) were injected with saline as control (C), adriamycin 3 ml/kg (Ad), saline with the left renal artery clipped (Rv), and adriamycin plus clip (AdRv). After 24 weeks mean arterial pressure (MAP), inulin, and p-aminohippurate (PAH) clearances were performed to evaluate renal function. Morphologic analysis included histologic criteria of percentage of glomerulosclerosis and tubulointerstitial lesion index (TILI). The MAP (mm Hg) was similar between Rv (143 +/- 13) and AdRv (154 +/- 20), but higher (P < .05) than C (120 +/- 8) and Ad (124 +/- 11). Inulin clearance (mL/min/100 g) in Ad (0.2 +/- 0.05) was smaller than in C (0.53 +/- 0.17) and Rv (0.4 +/- 0.01) (P < .05), and was at an intermediate level in AdRv (0.33 +/- 0.2). The level of PAH (mL/min/100 g) was normal at 1.76 in C, and diminished more in Ad (0.58) than in Rv (1.06) and AdRv (1.18) (P < .05). Both Ad and the AdRv nonclipped kidneys had the highest degree of glomerulosclerosis (33% and 25%) and TILI (7% and 8%), respectively, compared with C and Rv (both 0%), whereas the clipped kidneys displayed intermediate degrees (9% and 5%) (P < .05 v nonclipped). The data suggest that diminished perfusion pressure of the clipped kidney, by decreasing the intraglomerular pressure, protects the glomerulus from damage and attenuates the evolution of adriamycin nephropathy. Am J Hypertens 1998;11:1124-1128 (C) 1998 American Journal of Hypertension, Ltd.en
dc.description.affiliationUNESP, Botucata Med Sch, Dept Med, Botucatu, SP, Brazil
dc.description.affiliationBoston Univ, Sch Med, Dept Med, Hypertens Sect, Boston, MA 02118 USA
dc.description.affiliationUnespUNESP, Botucata Med Sch, Dept Med, Botucatu, SP, Brazil
dc.format.extent1124-1128
dc.identifierhttp://dx.doi.org/10.1016/S0895-7061(98)00119-8
dc.identifier.citationAmerican Journal of Hypertension. New York: Elsevier B.V., v. 11, n. 9, p. 1124-1128, 1998.
dc.identifier.doi10.1016/S0895-7061(98)00119-8
dc.identifier.issn0895-7061
dc.identifier.lattes5697804493071661
dc.identifier.lattes7095933557855151
dc.identifier.lattes5496411983893479
dc.identifier.orcid0000-0003-4979-4836
dc.identifier.urihttp://hdl.handle.net/11449/39195
dc.identifier.wosWOS:000075955000012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAmerican Journal of Hypertension
dc.relation.ispartofjcr3.046
dc.relation.ispartofsjr1,322
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectadriamycinpt
dc.subjectadriamycin nephropathypt
dc.subjectrenal hypoperfusionpt
dc.subjectprogression of nephropathypt
dc.subjecttwo-kidney-one-clip hypertensionpt
dc.titleRenal artery clipping attenuates the progression of adriamycin nephropathyen
dc.typeArtigo
dcterms.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5496411983893479[3]
unesp.author.lattes5697804493071661[1]
unesp.author.lattes7095933557855151
unesp.author.orcid0000-0003-4979-4836[3]
unesp.author.orcid0000-0001-8366-5064[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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