Cardiomyopathy and cell therapy: ejection fraction improvement and cardiac muscle mass increasing, after a year of bone marrow stem cells transplantation, by magnetic resonance image

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dc.contributor.authorGreco, Oswaldo Tadeu
dc.contributor.authorZotarelli Filho, Idiberto José
dc.contributor.authorBellini, Marilanda Ferreira
dc.contributor.authorBilaqui, Aldemir
dc.contributor.authorSouza Júnior, Artur Soares [UNESP]
dc.contributor.authorRuiz, Milton Artur
dc.contributor.authorAbreu, Ana Carolina de
dc.contributor.authorJacob, José Luiz Balthazar
dc.contributor.authorSantos, Adriana Barbosa [UNESP]
dc.contributor.institutionGreco – Cardiology, Arrhythmia and Pacemaker of São José do Rio Preto
dc.contributor.institutionInstituto de Moléstias Cardiovasculares (IMC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-04-27T11:55:53Z
dc.date.available2015-04-27T11:55:53Z
dc.date.issued2013
dc.description.abstractThe idiopathic dilated cardiomyopathy (IDC) is one of the major public health problems in the western world. Patients with IDC in functional class IV (New York Health Association - NYHA), even after therapeutic optimization, have high mortality. Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases and several positive effects were assigned to cell therapy in cardiomyopathy. The aim of this study was identify short-term result of cell transplantation in idiopathic dilated cardiomyopathy patients (IDC) who were treated by transplantation of autologous bone marrow mononuclear cells (BMMC). Intracoronary injections of autologous BMMC were performed in eight patients with severe ventricle dysfunction (mean of left ventricle ejection fraction – LEVF=20.03%), cardiac mass muscle around 156.2 g and NYHA between III and IV grades, other 8 IDC patients received placebo. The IDCs were followed - up for one and two years, by magnetic resonance imaging (MRI). The results after one year showed significant improvement in LVEF (mean=181.4) and muscle mass increasing (mean=181.4 g), after two years the LVEF continued improving, reaching a mean of 32.69% and the cardiac muscle mass kept stable (mean=179.4 g). Excepted for one patient, all the other had improvement in the NYHA functional class. The placebo group did not show any improvement. We believe that BMMC implant may be a beneficial therapeutic option for IDC patients.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciência da Computação e Estatística, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, RUA Cristovão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciência da Computação e Estatística, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto
dc.format.extent1-5
dc.identifierhttp://omicsonline.org/cardiomyopathy-cell-therapy-ejection-fraction-improvement-cardiac-muscle-mass-increasing-2157-7633.S6-008.php?aid=21435
dc.identifier.citationJournal of Stem Cell Reserach and Therapy, v. S6, n. 8, p. 1-5, 2013.
dc.identifier.doi10.4172/2157-7633.S6-008
dc.identifier.fileISSN2157-7633-2013-S6-08-01-05.pdf
dc.identifier.issn2157-7633
dc.identifier.lattes1538112904601391
dc.identifier.lattes7055362276236996
dc.identifier.lattes4873590040724241
dc.identifier.orcid0000-0003-4076-2475
dc.identifier.urihttp://hdl.handle.net/11449/122585
dc.language.isoeng
dc.relation.ispartofJournal of Stem Cell Reserach and Therapy
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectCardiomyopathyen
dc.subjectBone marrow mononuclear cells transplantationen
dc.subjectLeft ventricle ejection fractionen
dc.subjectCardiac muscle massen
dc.subjectMagnetic resonance imageen
dc.titleCardiomyopathy and cell therapy: ejection fraction improvement and cardiac muscle mass increasing, after a year of bone marrow stem cells transplantation, by magnetic resonance imageen
dc.typeArtigo
unesp.author.lattes1538112904601391
unesp.author.lattes7055362276236996[9]
unesp.author.lattes4873590040724241
unesp.author.orcid0000-0003-4076-2475[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentCiência da Computação e Estatísticapt

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