Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey

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dc.contributor.authorGranado, Marcos Donizete Junior
dc.contributor.authorPinato, Luciana [UNESP]
dc.contributor.authorSantiago, Jeferson
dc.contributor.authorBarbalho, Sandra Maria
dc.contributor.authorParmezzan, Jessica Ellen Lima
dc.contributor.authorSuzuki, Lenita Mayumi
dc.contributor.authorCabrini, Mayara Longui
dc.contributor.authorSpressão, Daniele Raineri Mesquita Serva
dc.contributor.authorCarneiro de Camargo, Ana Letícia
dc.contributor.authorGuissoni Campos, Leila Maria
dc.contributor.institutionUniversity of Marilia (UNIMAR)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T14:00:23Z
dc.date.available2023-07-29T14:00:23Z
dc.date.issued2022-12-20
dc.description.abstractMelatonin is a transducer of photic environmental information and participates in the synchronization of various physiological and behavioral phenomena. Melatonin can act directly in several areas of the central nervous system through its membrane receptors coupled to G protein, called MT1 and MT2 receptors. In some structures, such as the retina, hypothalamus and pars tuberalis, the expression of both melatonin receptors shows circadian variations. Melatonin can act in the synchronization of the clock proteins rhythm in these areas. Using the immunohistochemistry technique, we detected the immunoexpression of the melatonin receptors and clock genes clock protein Per1 in the inferior olivary nucleus (ION) of the Sapajus apella monkey at specific times of the light-dark phase. The mapping performed by immunohistochemistry showed expressive immunoreactivity (IR) Per1 with predominance during daytime. Both melatonin receptors were expressed in the ION without a day/night difference. The presence of both melatonin receptors and the Per1 protein in the inferior olivary nucleus can indicate a functional role not only in physiological, as in sleep, anxiety, and circadian rhythm, but also a chronobiotic role in motor control mechanisms.en
dc.description.affiliationPostgraduate Program in Structural and Functional Interactions in Rehabilitation Medical School University of Marilia (UNIMAR)
dc.description.affiliationDepartment of Speech Language and Hearing Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Speech Language and Hearing Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3389/fnins.2022.1072772
dc.identifier.citationFrontiers in Neuroscience, v. 16.
dc.identifier.doi10.3389/fnins.2022.1072772
dc.identifier.issn1662-453X
dc.identifier.issn1662-4548
dc.identifier.scopus2-s2.0-85145472766
dc.identifier.urihttp://hdl.handle.net/11449/249024
dc.language.isoeng
dc.relation.ispartofFrontiers in Neuroscience
dc.sourceScopus
dc.subjectbiological rhythms
dc.subjectclock genes
dc.subjectmelatonin
dc.subjectmotor
dc.subjectprimate
dc.titleMelatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkeyen
dc.typeArtigo

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