Effects of the acute exposition to glyphosate-based herbicide on oxidative stress parameters and antioxidant responses in a hybrid Amazon fish surubim (Pseudoplatystoma sp)

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dc.contributor.authorGindri Sinhorin, Valeria Dornelles
dc.contributor.authorSinhorin, Adilson Paulo
dc.contributor.authorSantos Teixeira, Jhonnes Marcos dos
dc.contributor.authorLazarotto Mileski, Kelly Marcia
dc.contributor.authorHansen, Paula Carine
dc.contributor.authorAndrade Moreira, Paula Sueli
dc.contributor.authorKawashita, Nair Honda
dc.contributor.authorBaviera, Amanda Martins [UNESP]
dc.contributor.authorLoro, Vania Lucia
dc.contributor.institutionUniv Fed Mato Grosso
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Santa Maria (UFSM)
dc.date.accessioned2014-12-03T13:09:12Z
dc.date.available2014-12-03T13:09:12Z
dc.date.issued2014-08-01
dc.description.abstractThe aim of this study was to investigate the effects of acute glyphosate (active ingredient) exposure on the oxidative stress biomarkers and antioxidant defenses of a hybrid surubim (Pseudoplatystoma sp). The fish were exposed to different herbicide concentrations for 96 h. The thiobarbituric acid-reactive substances (TBARS), protein carbonyls and antioxidant responses were verified. The 15 mg a.p L-1 of herbicide resulted in the death of 50% of the fish after 96 h. An increase in liver and muscle TBARS levels was observed when fish were exposed to the herbicide. The protein carbonyl content was also increased in the liver (4.5 mg a.p L-1 concentration) and brain (2.25 mg a.p L-1 concentration). The antioxidant activities decreased in the liver and brain after exposure to herbicide. Levels of ascorbic acid in the liver (2.25 mg a.p L-1 and 4.5 mg a.p L-1 concentrations) and brain (2.25 mg a.p L-1 concentration) were increased post-treatment. Levels of total thiols were increased in the liver and brain (2.25 mg L-1 and 7.5 mg a.p L-1, respectively). Glyphosate exposure, at the tested concentrations affects surubim health by promoting changes that can affect their survival in natural environment. Some parameters as TBARS and protein carbonyl could be early biomarkers for Roundup exposure in this fish species. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Mato Grosso, Inst Ciancias Nat Humanas & Sociais, Lab Integrados Pesquisas Quim, Cuiaba, MT, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Ciencias Saude, Cuiaba, MT, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Ciencias Agr & Ambientais, Cuiaba, MT, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Ciencias Exatas & Terra, Cuiaba, MT, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Ciancias Farmacaut, Dept Andlises Clin, Campus De Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Santa Maria, Lab Bioquim Adaptat & Toxicol Peixes, BR-97119900 Santa Maria, RS, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Fac Ciancias Farmacaut, Dept Andlises Clin, Campus De Araraquara, SP, Brazil
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Mato Grosso
dc.description.sponsorshipIdFAPEMAT: 304283-2010
dc.format.extent181-187
dc.identifierhttp://dx.doi.org/10.1016/j.ecoenv.2014.04.040
dc.identifier.citationEcotoxicology And Environmental Safety. San Diego: Academic Press Inc Elsevier Science, v. 106, p. 181-187, 2014.
dc.identifier.doi10.1016/j.ecoenv.2014.04.040
dc.identifier.issn0147-6513
dc.identifier.lattes3736475025187750
dc.identifier.urihttp://hdl.handle.net/11449/112061
dc.identifier.wosWOS:000337643800024
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEcotoxicology and Environmental Safety
dc.relation.ispartofjcr3.974
dc.relation.ispartofsjr1,201
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectFish farmersen
dc.subjectHybrid Amazon fishen
dc.subjectPesticideen
dc.subjectOxidative stressen
dc.subjectSoybean monocultureen
dc.subjectRoundupen
dc.titleEffects of the acute exposition to glyphosate-based herbicide on oxidative stress parameters and antioxidant responses in a hybrid Amazon fish surubim (Pseudoplatystoma sp)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3736475025187750[8]
unesp.author.orcid0000-0003-0987-5295[8]
unesp.author.orcid0000-0003-2440-8791[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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