Use of fibrin glue derived from snake venom in testicular biopsy of rams

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dc.contributor.authorSartori Filho, Roberto [UNESP]
dc.contributor.authorPrestes, Nereu Carlos [UNESP]
dc.contributor.authorThomazini, I. A. [UNESP]
dc.contributor.authorMendes Giannini, Maria José Soares [UNESP]
dc.contributor.authorToscano, E. [UNESP]
dc.contributor.authorCanavessi, A. M O [UNESP]
dc.contributor.authorBarraviera, B. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:32Z
dc.date.available2014-05-27T11:19:32Z
dc.date.issued1998-01-01
dc.description.abstractSequelae due to testicular biopsy such as hemorrhage, adhesion and fibrosis may be limiting factors to the use of this surgical procedure. Fibrin glue (FG) derived from snake venom was used to minimize these sequelae, as well as to evaluate its healing property in tunica vaginalis and scrotal skin of rams. Applicability of fibrin glue derived from snake venom was tested in different tissues of other animals such as in sciatic nerve and colon of rats and skin of rabbits. In the present study, 30 healthy adult rams were used. They were divided into 3 groups of 10 animals each as follows: G1: fibrin glue group (application of fibrin glue on puncture sites and skin incisions after bilateral testicular biopsy with a Tru-Cut needle); G2: swab/nylon group (hemostasis by compression with a swab on puncture sites and skin suturing with nylon after biopsy) and G3: control group (the animals were not subjected either to biopsy or to surgery). On the 20th day after biopsy, the presence of adhesion strands between the sites of skin incision and testicle was evaluated by palpation Adhesion strands were found in three testicles (15%) in G1 and in two testicles (10%) in G2. One hundred days after biopsy, orchiectomy was carried out and the material collected was assessed for subcutaneous (SC) and/or tunica vaginalis adhesions. G3 did not present any abnormality. Groups G1 and G2 presented four testicles each (20%) with adhesion between the tunics at biopsy site. On the other hand, subcutaneous adhesions were found once (5%) in G1 and three times (15%) in G2. Fibrin glue showed to be of easy application, required short postoperative monitoring, presented fast and good-quality healing property and tended to reduce formation of subcutaneous adhesion.en
dc.description.affiliationDept Reprod Animal Radiol Veterin FMVZ UNESP, CEP 18.618-000, Botucatu, Sao Paulo
dc.description.affiliationUnespDept Reprod Animal Radiol Veterin FMVZ UNESP, CEP 18.618-000, Botucatu, Sao Paulo
dc.format.extent23-35
dc.identifierhttp://dx.doi.org/10.1590/S0104-79301998000100003
dc.identifier.citationJournal of Venomous Animals and Toxins, v. 4, n. 1, p. 23-35, 1998.
dc.identifier.doi10.1590/S0104-79301998000100003
dc.identifier.issn0104-7930
dc.identifier.lattes5946482110081687
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.scieloS0104-79301998000100003
dc.identifier.scopus2-s2.0-0031984063
dc.identifier.urihttp://hdl.handle.net/11449/65372
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiopsy
dc.subjectFibrin tecidual adhesive
dc.subjectOvine
dc.subjectSnake venoms
dc.subjectTesticle
dc.subjectfibrin glue
dc.subjectnylon
dc.subjectsnake venom
dc.subjectadhesion
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectbleeding
dc.subjectcolon
dc.subjectcompression
dc.subjectcontrolled study
dc.subjectfibrosis
dc.subjecthealing
dc.subjecthemostasis
dc.subjectmale
dc.subjectnonhuman
dc.subjectorchiectomy
dc.subjectpalpation
dc.subjectrabbit
dc.subjectrat
dc.subjectsciatic nerve
dc.subjectscrotum
dc.subjectsheep
dc.subjectskin
dc.subjectskin incision
dc.subjectsurgical technique
dc.subjecttestis biopsy
dc.subjecttopical drug administration
dc.subjecttunica vaginalis
dc.titleUse of fibrin glue derived from snake venom in testicular biopsy of ramsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvat/iaboutj.htm
unesp.author.lattes5946482110081687
unesp.author.lattes6840524602748457[7]
unesp.author.orcid0000-0002-9855-5594[7]
unesp.author.orcid0000-0002-8059-0826[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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