Susceptibility profile of a Brazilian yeast stock collection of Candida species isolated from subjects with Candida-associated denture stomatitis with or without diabetes

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dc.contributor.authorSanitá, Paula Volpato
dc.contributor.authorde Oliveira Mima, Ewerton Garcia
dc.contributor.authorPavarina, Ana Claudia [UNESP]
dc.contributor.authorJorge, Janaina Habib [UNESP]
dc.contributor.authorMachado, Ana Lucia [UNESP]
dc.contributor.authorVergani, Carlos Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:43Z
dc.date.available2014-05-27T11:30:43Z
dc.date.issued2013-09-20
dc.description.abstractObjective: This study investigated the susceptibility of 198 clinical isolates of Candida species against caspofungin, amphotericin B, itraconazole, and fluconazole. Study Design: Suspensions of the microorganisms were spread on Roswell Park Memorial Institute (RPMI) agar plates. Etest strips were placed on the plates, and the minimal inhibitory concentration (MIC) was read after incubation (48 h at 37°C). Data were analyzed by a factorial analysis of variance and a 2 × 2 post hoc test (α = .05). Results: C glabrata showed the highest MIC values (P < .001) against caspofungin, itraconazole, and fluconazole. For amphotericin B, the MIC values of C tropicalis and C glabrata (P = .0521) were higher than those of C albicans (P < .001). Itraconazole was the least effective antifungal; 93.3% of the C glabrata isolates, 3.3% of the C albicans, and 1.3% of the C tropicalis were resistant. All microorganisms were susceptible to caspofungin and amphotericin B. Conclusions: Caspofungin and amphotericin B should be recommended as an effective alternative for the management of oral Candida infections when treatment with topical or other systemic drugs has definitely failed. © 2013 Elsevier Inc. All rights reserved.en
dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2013.07.002
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.
dc.identifier.doi10.1016/j.oooo.2013.07.002
dc.identifier.issn2212-4403
dc.identifier.lattes8867670539105403
dc.identifier.lattes8000248781842587
dc.identifier.lattes3003130522427820
dc.identifier.orcid0000-0002-7375-4714
dc.identifier.scopus2-s2.0-84884174630
dc.identifier.urihttp://hdl.handle.net/11449/76605
dc.identifier.wosWOS:000325424000022
dc.language.isoeng
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.relation.ispartofjcr1.718
dc.relation.ispartofsjr0,720
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.titleSusceptibility profile of a Brazilian yeast stock collection of Candida species isolated from subjects with Candida-associated denture stomatitis with or without diabetesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes8867670539105403[3]
unesp.author.lattes8000248781842587[5]
unesp.author.lattes3003130522427820[6]
unesp.author.orcid0000-0002-7375-4714[6]
unesp.author.orcid0000-0002-9135-3455[4]
unesp.author.orcid0000-0002-9231-1994[3]
unesp.author.orcid0000-0002-2718-428X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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